InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cxcl2

Summary

InnateDB Gene

IDBG-178955.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cxcl2

Gene Name

chemokine (C-X-C motif) ligand 2

Synonyms

CINC-2a; Gro2; GROb; Mgsa-b; MIP-2; MIP-2a; Mip2; Scyb; Scyb2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000058427

Encoded Proteins

IDBP-178957

chemokine (C-X-C motif) ligand 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21757770

Cxcl2 is a chemokine secreted by kidney dendritic cells to recruit neutrophils to sites of uropathogenic bacterial infection.

PMID 25447519

Cebpa suppresses granule formation in mast cells and increases Cxcl2 production from mast cells upon bacterial stimulation.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163734:
This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. [provided by RefSeq, Sep 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:90903899-90905909

Strand

Forward strand

Band

Transcripts

ENSMUST00000075433

ENSMUSP00000074885

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	4 [view]
Protein-DNA	8 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008009	chemokine activity

Biological Process

GO:0001975	response to amphetamine
GO:0002237	response to molecule of bacterial origin
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0009408	response to heat
GO:0010332	response to gamma radiation
GO:0030593	neutrophil chemotaxis
GO:0030595	leukocyte chemotaxis
GO:0032355	response to estradiol
GO:0042060	wound healing
GO:0045087	innate immune response (InnateDB)
GO:0051384	response to glucocorticoid
GO:0070997	neuron death
GO:0071222	cellular response to lipopolysaccharide
GO:0071347	cellular response to interleukin-1