Version 5.4
Mus musculus Gene: Atg7
Summary
InnateDB Gene IDBG-178961.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Atg7
Gene Name autophagy related 7
Synonyms 1810013K23Rik; Agp7; Apg7l; Atg7l; Gm21553
Species Mus musculus
Ensembl Gene ENSMUSG00000030314
Encoded Proteins
IDBP-178963
autophagy-related 7 (yeast)
IDBP-626374
autophagy-related 7 (yeast)
IDBP-790147
autophagy related 7
IDBP-790148
autophagy related 7
IDBP-790149
autophagy related 7
IDBP-790150
autophagy related 7
IDBP-790151
autophagy related 7
IDBP-790152
autophagy related 7
IDBP-790153
autophagy related 7
IDBP-790154
autophagy related 7
IDBP-790155
autophagy related 7
IDBP-790156
autophagy related 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 25512546
Atg7 plays an essential role for autophagy during invariant natural killer T cell development.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000197548:
This gene was identified based on homology to Pichia pastoris GSA7 and Saccharomyces cerevisiae APG7. In the yeast, the protein appears to be required for fusion of peroxisomal and vacuolar membranes. The protein shows homology to the ATP-binding and catalytic sites of the E1 ubiquitin activating enzymes. [provided by RefSeq, Jan 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:114643097-114860614
Strand Forward strand
Band E3
Transcripts
ENSMUST00000032457 ENSMUSP00000032457
ENSMUST00000169310 ENSMUSP00000133215
ENSMUST00000183127
ENSMUST00000182169 ENSMUSP00000138404
ENSMUST00000183165 ENSMUSP00000138600
ENSMUST00000182098 ENSMUSP00000138253
ENSMUST00000182793 ENSMUSP00000138137
ENSMUST00000182902 ENSMUSP00000138651
ENSMUST00000182428 ENSMUSP00000138779
ENSMUST00000182035 ENSMUSP00000138731
ENSMUST00000182510 ENSMUSP00000138300
ENSMUST00000182034 ENSMUSP00000138358
ENSMUST00000182771 ENSMUSP00000138374
ENSMUST00000182860
ENSMUST00000182934
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 20 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004839 ubiquitin activating enzyme activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0019778 Atg12 activating enzyme activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0001889 liver development
GO:0006497 protein lipidation
GO:0006520 cellular amino acid metabolic process
GO:0006914 autophagy
GO:0006996 organelle organization
GO:0007005 mitochondrion organization
GO:0007628 adult walking behavior
GO:0009267 cellular response to starvation
GO:0009791 post-embryonic development
GO:0010508 positive regulation of autophagy
GO:0015031 protein transport
GO:0016239 positive regulation of macroautophagy
GO:0016567 protein ubiquitination
GO:0021680 cerebellar Purkinje cell layer development
GO:0021860 pyramidal neuron development
GO:0021955 central nervous system neuron axonogenesis
GO:0021987 cerebral cortex development
GO:0030163 protein catabolic process
GO:0031175 neuron projection development
GO:0031396 regulation of protein ubiquitination
GO:0031401 positive regulation of protein modification process
GO:0032446 protein modification by small protein conjugation
GO:0039689 negative stranded viral RNA replication
GO:0042594 response to starvation
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0045732 positive regulation of protein catabolic process
GO:0050877 neurological system process
GO:0055013 cardiac muscle cell development
GO:0061024 membrane organization
GO:0071455 cellular response to hyperoxia
Cellular Component
GO:0000407 pre-autophagosomal structure
GO:0005737 cytoplasm
GO:0005930 axoneme
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000197548
View Gene Order
ENSBTAG00000035827
Not yet available
Pathways
NETPATH
REACTOME
REACT_236645
Class I MHC mediated antigen processing & presentation pathway
REACT_230745
Immune System pathway
REACT_199115
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_229531
Adaptive Immune System pathway
KEGG
mmu04140
Regulation of autophagy pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
KEGG
hsa04140
Regulation of autophagy pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL S4R1K1 S4R1U3
UniProt Splice Variant
Entrez Gene 74244
UniGene
RefSeq NM_001253717 NM_001253718 NM_028835 XM_006506707 XM_006506708 XM_006506709 XM_006506710
OMIM
CCDS CCDS39598 CCDS59697
HPRD
IMGT
MGI ID MGI:1921494
MGI Symbol Atg7
EMBL AC122843 AC149276 AC170088
GenPept
RNA Seq Atlas 74244

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca