InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pparg

Summary

InnateDB Gene

IDBG-179253.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pparg

Gene Name

peroxisome proliferator activated receptor gamma

Synonyms

Nr1c3; PPAR-gamma; PPAR-gamma2; PPARgamma; PPARgamma2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000000440

Encoded Proteins

IDBP-179255

peroxisome proliferator activated receptor gamma

IDBP-626496

peroxisome proliferator activated receptor gamma

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21148557

Pparg negatively regulates Ifnb production in Tlr3/4 stimulated macrophages by preventing Irf3 binding to the Ifnb promoter.

PMID 23071818

The loss of PPARγ in T cells increased colitis disease activity and colonic inflammatory lesions following Clostridium difficile infection.

InnateDB Annotation from Orthologs

Summary

PMID 20421464

[Homo sapiens] PPARG functions as an antimicrobial factor by maintaining constitutive epithelial expression of a subset of beta-defensin in the colon.

PMID 21148557

[Homo sapiens] PPARG negatively regulates IFNB production in TLR3/4-stimulated macrophages by preventing IRF3 binding to the IFN-beta promoter.

PMID 25595716

[Homo sapiens] MIR130A reduces hepatitis B virus (HBV) replication by down-regulating the expression of two major metabolic regulators PPARGC1A and PPARG, both of which can potently stimulate HBV replication.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000132170:
This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:115361221-115490401

Strand

Forward strand

Band

Transcripts

ENSMUST00000000450	ENSMUSP00000000450
ENSMUST00000171644	ENSMUSP00000131962

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 104 interaction(s) predicted by orthology.

Experimentally validated
Total	38 [view]
Protein-Protein	32 [view]
Protein-DNA	6 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	104 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001012	RNA polymerase II regulatory region DNA binding
GO:0001228	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0008144	drug binding
GO:0008270	zinc ion binding
GO:0019899	enzyme binding
GO:0019903	protein phosphatase binding
GO:0030331	estrogen receptor binding
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity
GO:0033613	activating transcription factor binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0046965	retinoid X receptor binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001890	placenta development
GO:0002674	negative regulation of acute inflammatory response
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006954	inflammatory response
GO:0007165	signal transduction
GO:0007507	heart development
GO:0008217	regulation of blood pressure
GO:0008285	negative regulation of cell proliferation
GO:0009409	response to cold
GO:0009612	response to mechanical stimulus
GO:0010033	response to organic substance
GO:0010871	negative regulation of receptor biosynthetic process
GO:0010887	negative regulation of cholesterol storage
GO:0010891	negative regulation of sequestering of triglyceride
GO:0014070	response to organic cyclic compound
GO:0015909	long-chain fatty acid transport
GO:0019216	regulation of lipid metabolic process
GO:0019395	fatty acid oxidation
GO:0030224	monocyte differentiation
GO:0030308	negative regulation of cell growth
GO:0030855	epithelial cell differentiation
GO:0031000	response to caffeine
GO:0031100	organ regeneration
GO:0032526	response to retinoic acid
GO:0032869	cellular response to insulin stimulus
GO:0032966	negative regulation of collagen biosynthetic process
GO:0033189	response to vitamin A
GO:0033993	response to lipid
GO:0035357	peroxisome proliferator activated receptor signaling pathway
GO:0035902	response to immobilization stress
GO:0036270	response to diuretic
GO:0042493	response to drug
GO:0042593	glucose homeostasis
GO:0042594	response to starvation
GO:0042953	lipoprotein transport
GO:0043065	positive regulation of apoptotic process
GO:0043401	steroid hormone mediated signaling pathway
GO:0043627	response to estrogen
GO:0045087	innate immune response (InnateDB)
GO:0045165	cell fate commitment
GO:0045444	fat cell differentiation
GO:0045598	regulation of fat cell differentiation
GO:0045600	positive regulation of fat cell differentiation
GO:0045713	low-density lipoprotein particle receptor biosynthetic process
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046321	positive regulation of fatty acid oxidation
GO:0048469	cell maturation
GO:0048662	negative regulation of smooth muscle cell proliferation
GO:0048714	positive regulation of oligodendrocyte differentiation
GO:0050872	white fat cell differentiation
GO:0050873	brown fat cell differentiation
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051974	negative regulation of telomerase activity
GO:0055098	response to low-density lipoprotein particle stimulus
GO:0060100	positive regulation of phagocytosis, engulfment
GO:0060336	negative regulation of interferon-gamma-mediated signaling pathway
GO:0071285	cellular response to lithium ion
GO:0071300	cellular response to retinoic acid
GO:0071306	cellular response to vitamin E
GO:0071379	cellular response to prostaglandin stimulus
GO:0071380	cellular response to prostaglandin E stimulus
GO:0071407	cellular response to organic cyclic compound
GO:0071455	cellular response to hyperoxia
GO:1901558	response to metformin
GO:2000230	negative regulation of pancreatic stellate cell proliferation