InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Nr1h2

Summary

InnateDB Gene

IDBG-179265.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nr1h2

Gene Name

nuclear receptor subfamily 1, group H, member 2

Synonyms

AI194859; LXR; LXRB; LXRbeta; NER1; OR-1; RIP15; Unr; Unr2; UR

Species

Mus musculus

Ensembl Gene

ENSMUSG00000060601

Encoded Proteins

IDBP-179267

nuclear receptor subfamily 1, group H, member 2

IDBP-265669

nuclear receptor subfamily 1, group H, member 2

IDBP-265671

nuclear receptor subfamily 1, group H, member 2

IDBP-265673

nuclear receptor subfamily 1, group H, member 2

IDBP-627884

nuclear receptor subfamily 1, group H, member 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000131408:
The liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009 [PubMed 19436111]).[supplied by OMIM, Jan 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:44549616-44553951

Strand

Reverse strand

Band

Transcripts

ENSMUST00000073488	ENSMUSP00000073188
ENSMUST00000107912	ENSMUSP00000103545
ENSMUST00000107911	ENSMUSP00000103544
ENSMUST00000107910	ENSMUSP00000103543
ENSMUST00000123358
ENSMUST00000128354
ENSMUST00000132769
ENSMUST00000137674
ENSMUST00000141901
ENSMUST00000128600
ENSMUST00000142298
ENSMUST00000136611
ENSMUST00000167197	ENSMUSP00000126788

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 53 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	53 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001133	sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0034191	apolipoprotein A-I receptor binding
GO:0043565	sequence-specific DNA binding
GO:0046965	retinoid X receptor binding
GO:0051117	ATPase binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0010628	positive regulation of gene expression
GO:0010629	negative regulation of gene expression
GO:0010867	positive regulation of triglyceride biosynthetic process
GO:0010875	positive regulation of cholesterol efflux
GO:0010884	positive regulation of lipid storage
GO:0010887	negative regulation of cholesterol storage
GO:0030522	intracellular receptor signaling pathway
GO:0032270	positive regulation of cellular protein metabolic process
GO:0032369	negative regulation of lipid transport
GO:0032376	positive regulation of cholesterol transport
GO:0042632	cholesterol homeostasis
GO:0043401	steroid hormone mediated signaling pathway
GO:0044255	cellular lipid metabolic process
GO:0045723	positive regulation of fatty acid biosynthetic process
GO:0045861	negative regulation of proteolysis
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048384	retinoic acid receptor signaling pathway
GO:0048550	negative regulation of pinocytosis
GO:0051006	positive regulation of lipoprotein lipase activity
GO:0055088	lipid homeostasis
GO:0090108	positive regulation of high-density lipoprotein particle assembly
GO:0090187	positive regulation of pancreatic juice secretion
GO:0090340	positive regulation of secretion of lysosomal enzymes
GO:2000188	regulation of cholesterol homeostasis

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000131408

View Gene Order

ENSBTAG00000003264

Not yet available

Pathways

NETPATH

REACTOME

REACT_234105

Nuclear Receptor transcription pathway pathway

REACT_233572

Gene Expression pathway

REACT_206529

Generic Transcription Pathway pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_15525

Nuclear Receptor transcription pathway pathway

REACT_12627

Generic Transcription Pathway pathway

REACT_71

Gene Expression pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.968

RefSeq

NM_001285517 NM_001285518 NM_001285519 NM_009473 XM_006540804

OMIM

CCDS

CCDS21211 CCDS71947

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas