InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Huwe1

Summary

InnateDB Gene

IDBG-179321.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Huwe1

Gene Name

HECT, UBA and WWE domain containing 1

Synonyms

5430439H10Rik; Arf-bp1; AU041296; C430014N20Rik; C80292; Gm1718; Ib772; LASU1; Mule; Ureb1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000025261

Encoded Proteins

IDBP-179323

HECT, UBA and WWE domain containing 1

IDBP-255548

HECT, UBA and WWE domain containing 1

IDBP-532898

HECT, UBA and WWE domain containing 1

IDBP-537551

HECT, UBA and WWE domain containing 1

IDBP-539606

HECT, UBA and WWE domain containing 1

IDBP-536721

HECT, UBA and WWE domain containing 1

IDBP-540391

HECT, UBA and WWE domain containing 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000086758:
This gene encodes a member of the HECT E3 ubiquitin ligase family. The HECT domain lies in the C-terminus and contains the active-site cysteine which forms an intermediate ubiquitin-thioester bond. E3 family members are divided into three subfamilies based on their protein-protein interaction domains; this gene encodes a member of the SI(ngle)-HECT E3 subfamily. In lung, breast, and colorectal carcinomas, this gene is highly expressed. Mutations in this gene has been found in 3 unrelated families with X-linked syndromic mental retardation, Turner type. [provided by RefSeq, Nov 2009]
This gene encodes a protein containing a C-terminal HECT (E6AP type E3 ubiquitin protein ligase) domain that functions as an E3 ubiquitin ligase. The encoded protein is required for the ubiquitination and subsequent degradation of the anti-apoptotic protein Mcl1 (myeloid cell leukemia sequence 1 (BCL2-related)). This protein also ubiquitinates the p53 tumor suppressor, core histones, and DNA polymerase beta. Mutations in this gene are associated with Turner type X-linked syndromic mental retardation. [provided by RefSeq, Aug 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:151800807-151935417

Strand

Forward strand

Band

Transcripts

ENSMUST00000026292	ENSMUSP00000026292
ENSMUST00000112622	ENSMUSP00000108241
ENSMUST00000129714
ENSMUST00000139386
ENSMUST00000152757
ENSMUST00000153687	ENSMUSP00000114862
ENSMUST00000149344
ENSMUST00000137816
ENSMUST00000130243
ENSMUST00000131786
ENSMUST00000156616	ENSMUSP00000114357
ENSMUST00000150020
ENSMUST00000147666
ENSMUST00000138566	ENSMUSP00000122612
ENSMUST00000138023	ENSMUSP00000120057
ENSMUST00000123306	ENSMUSP00000118185
ENSMUST00000150882
ENSMUST00000150426
ENSMUST00000132453
ENSMUST00000139909
ENSMUST00000133051
ENSMUST00000130234
ENSMUST00000139245

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 52 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	52 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0004842	ubiquitin-protein transferase activity
GO:0005488	binding
GO:0005515	protein binding
GO:0016874	ligase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000209	protein polyubiquitination
GO:0006284	base-excision repair
GO:0006513	protein monoubiquitination
GO:0016574	histone ubiquitination
GO:0030154	cell differentiation
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process