Version 5.4
Mus musculus Gene: Erbb2ip
Summary
InnateDB Gene IDBG-179382.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Erbb2ip
Gene Name Erbb2 interacting protein
Synonyms 1700028E05Rik; Erbin; mKIAA1225
Species Mus musculus
Ensembl Gene ENSMUSG00000021709
Encoded Proteins
IDBP-179384
Erbb2 interacting protein
IDBP-179386
Erbb2 interacting protein
IDBP-179388
Erbb2 interacting protein
IDBP-625932
Erbb2 interacting protein
IDBP-788293
Erbb2 interacting protein
IDBP-788300
Erbb2 interacting protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 16203728
[Homo sapiens] ERBB2IP ccts as a negative regulator of the MDP-mediated activation of NF-kappaB by NOD2.
PMID 16203728
[Homo sapiens] ERBB2IP overexpression inhibits NOD2-dependent cytokine secretion in mouse embryonic fibroblasts.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000112851:
This gene is a member of the leucine-rich repeat and PDZ domain (LAP) family. The encoded protein contains 17 leucine-rich repeats and one PDZ domain. It binds to the unphosphorylated form of the ERBB2 protein and regulates ERBB2 function and localization. It has also been shown to affect the Ras signaling pathway by disrupting Ras-Raf interaction. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:103818787-103920514
Strand Reverse strand
Band D1
Transcripts
ENSMUST00000053927 ENSMUSP00000057956
ENSMUST00000091269 ENSMUSP00000088813
ENSMUST00000022222 ENSMUSP00000022222
ENSMUST00000169083 ENSMUSP00000127607
ENSMUST00000188997 ENSMUSP00000140931
ENSMUST00000191275 ENSMUSP00000140536
ENSMUST00000189323
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 71 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 71 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005178 integrin binding
GO:0005515 protein binding
Biological Process
GO:0006605 protein targeting
GO:0045087 innate immune response
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016323 basolateral plasma membrane
GO:0030056 hemidesmosome
GO:0031965 nuclear membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000112851
View Gene Order
ENSBTAG00000000415
Not yet available
Pathways
NETPATH
REACTOME
REACT_188191
Signaling by ERBB2 pathway
REACT_188257
Signal Transduction pathway
KEGG
mmu04621
NOD-like receptor signaling pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_1
Alpha6Beta4Integrin pathway
NetPath_4
EGFR1 pathway
NetPath_7
TGF_beta_Receptor pathway
NetPath_11
TCR pathway
REACTOME
REACT_115755
Signaling by ERBB2 pathway
REACT_111102
Signal Transduction pathway
KEGG
hsa04621
NOD-like receptor signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL B2RUK2
UniProt Splice Variant
Entrez Gene 59079
UniGene
RefSeq NM_001005868 NM_001289473 NM_001289474 NM_001289475 NM_021563
OMIM
CCDS CCDS26744
HPRD
IMGT
MGI ID MGI:1890169
MGI Symbol Erbb2ip
EMBL BC141188
GenPept AAI41189
RNA Seq Atlas 59079

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca