Version 5.4
Homo sapiens Gene: IFI27
Summary
InnateDB Gene IDBG-17962.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IFI27
Gene Name interferon, alpha-inducible protein 27
Synonyms FAM14D; ISG12; ISG12A; P27
Species Homo sapiens
Ensembl Gene ENSG00000165949
Encoded Proteins
IDBP-594522
interferon, alpha-inducible protein 27
IDBP-807957
interferon, alpha-inducible protein 27
IDBP-807966
interferon, alpha-inducible protein 27
IDBP-807968
interferon, alpha-inducible protein 27
IDBP-807969
interferon, alpha-inducible protein 27
IDBP-807971
interferon, alpha-inducible protein 27
IDBP-807972
interferon, alpha-inducible protein 27
IDBP-807973
interferon, alpha-inducible protein 27
IDBP-807974
interferon, alpha-inducible protein 27
IDBP-807975
interferon, alpha-inducible protein 27
IDBP-807976
interferon, alpha-inducible protein 27
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 20939681
IFI27 is a mitochondrial protein and its expression sensitizes cells to apoptotic stimuli via mitochondrial membrane destabilization.
PMID 27194766
IFI27 restricts viral infection by recruiting an E3 ligase, SKP2, for ubiquitination and degradation of viral protein.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 14:94104836-94116698
Strand Forward strand
Band q32.12
Transcripts
ENST00000555081
ENST00000557700
ENST00000555819 ENSP00000451987
ENST00000614204 ENSP00000479250
ENST00000618863 ENSP00000482635
ENST00000611954 ENSP00000483404
ENST00000618200 ENSP00000478718
ENST00000621160 ENSP00000483498
ENST00000620396 ENSP00000483954
ENST00000612813 ENSP00000483430
ENST00000612499
ENST00000614288 ENSP00000483072
ENST00000614648
ENST00000616764 ENSP00000477753
ENST00000620066 ENSP00000482832
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 3 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0016021 integral component of membrane
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001288952 NM_001288954 NM_001288957 NM_001288958 NM_001288960 NM_001288995 NM_005532
HUGO
OMIM
CCDS CCDS32148
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca