InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Srebf1

Summary

InnateDB Gene

IDBG-179865.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Srebf1

Gene Name

sterol regulatory element binding transcription factor 1

Synonyms

ADD-1; ADD1; bHLHd1; D630008H06; SREBP-1; SREBP-1a; SREBP-1c; SREBP1; SREBP1c

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020538

Encoded Proteins

IDBP-179867

sterol regulatory element binding transcription factor 1

IDBP-535143

sterol regulatory element binding transcription factor 1

IDBP-541057

sterol regulatory element binding transcription factor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21531336

Srebf1 deficient mice are resistant to endotoxic shock and systemic inflammatory response syndrome induced by cecal ligation and puncture. Srebf1 is not only necessary for transcription of lipogenesis genes in macrophages, but is also responsible for the expression of Nlrp1a, which is a core inflammasome component.

InnateDB Annotation from Orthologs

Summary

PMID 21531336

[Homo sapiens] SREBF1 deficient mice are resistant to endotoxic shock and systemic inflammatory response syndrome induced by cecal ligation and puncture. SREBF1 is not only a necessary transcription factor for lipogenesis genes in macrophages, but is also responsible for the expression of NLRP1A, which is a core inflammasome component. (Demonstrated in murine model)

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000072310:
This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:60199089-60222581

Strand

Reverse strand

Band

Transcripts

ENSMUST00000020846	ENSMUSP00000020846
ENSMUST00000134660	ENSMUSP00000122934
ENSMUST00000141161
ENSMUST00000144942	ENSMUSP00000120777
ENSMUST00000129869
ENSMUST00000156304
ENSMUST00000154925
ENSMUST00000136426
ENSMUST00000149238
ENSMUST00000154620
ENSMUST00000147967
ENSMUST00000136215

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 54 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	12 [view]
Protein-DNA	6 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	54 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0032403	protein complex binding
GO:0032810	sterol response element binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0046983	protein dimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0003062	regulation of heart rate by chemical signal
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007568	aging
GO:0007623	circadian rhythm
GO:0008203	cholesterol metabolic process
GO:0008286	insulin receptor signaling pathway
GO:0008610	lipid biosynthetic process
GO:0009267	cellular response to starvation
GO:0009749	response to glucose
GO:0010867	positive regulation of triglyceride biosynthetic process
GO:0019217	regulation of fatty acid metabolic process
GO:0030324	lung development
GO:0031065	positive regulation of histone deacetylation
GO:0032094	response to food
GO:0032526	response to retinoic acid
GO:0032570	response to progesterone
GO:0032869	cellular response to insulin stimulus
GO:0033762	response to glucagon
GO:0033993	response to lipid
GO:0042493	response to drug
GO:0043434	response to peptide hormone
GO:0045087	innate immune response (InnateDB)
GO:0045542	positive regulation of cholesterol biosynthetic process
GO:0045723	positive regulation of fatty acid biosynthetic process
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046676	negative regulation of insulin secretion
GO:0050796	regulation of insulin secretion
GO:0051591	response to cAMP
GO:0070542	response to fatty acid
GO:0071398	cellular response to fatty acid

Cellular Component

GO:0000139	Golgi membrane
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0012507	ER to Golgi transport vesicle membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0043234	protein complex