InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Med25

Summary

InnateDB Gene

IDBG-180153.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Med25

Gene Name

mediator of RNA polymerase II transcription, subunit 25 homolog (yeast)

Synonyms

2610034E13Rik; 2610529E18Rik; ESTM2; X83308

Species

Mus musculus

Ensembl Gene

ENSMUSG00000002968

Encoded Proteins

IDBP-180155

mediator of RNA polymerase II transcription, subunit 25 homolog (yeast)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000104973:
This gene encodes a component of the transcriptional coactivator complex termed the Mediator complex. This complex is required for transcription of most RNA polymerase II-dependent genes. The encoded protein plays a role in chromatin modification and in preinitiation complex assembly. Mutations in this gene are associated with Charcot-Marie-Tooth disease type 2B2. [provided by RefSeq, Apr 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:44879391-44892397

Strand

Reverse strand

Band

Transcripts

ENSMUST00000003049

ENSMUSP00000003049

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 43 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	43 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0042974	retinoic acid receptor binding
GO:0046965	retinoid X receptor binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0035563	positive regulation of chromatin binding
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048147	negative regulation of fibroblast proliferation
GO:0071158	positive regulation of cell cycle arrest
GO:2001178	positive regulation of mediator complex assembly