Version 5.4
Mus musculus Gene: Dscam
Summary
InnateDB Gene IDBG-180173.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dscam
Gene Name Down syndrome cell adhesion molecule
Synonyms 4932410A21Rik
Species Mus musculus
Ensembl Gene ENSMUSG00000050272
Encoded Proteins
IDBP-180175
Down syndrome cell adhesion molecule
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171587:
This gene is a member of the immunoglobulin superfamily of cell adhesion molecules (Ig-CAMs), and is involved in human central and peripheral nervous system development. This gene is a candidate for Down syndrome and congenital heart disease (DSCHD). A gene encoding a similar Ig-CAM protein is located on chromosome 11. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:96592079-97170752
Strand Reverse strand
Band C4
Transcripts
ENSMUST00000056102 ENSMUSP00000056040
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007155 cell adhesion
GO:0007162 negative regulation of cell adhesion
GO:0007626 locomotory behavior
GO:0042327 positive regulation of phosphorylation
GO:0048813 dendrite morphogenesis
GO:0048842 positive regulation of axon extension involved in axon guidance
GO:0060060 post-embryonic retina morphogenesis in camera-type eye
GO:0070593 dendrite self-avoidance
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0030424 axon
GO:0030426 growth cone
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000171587
View Gene Order
ENSBTAG00000004754
Not yet available
Pathways
NETPATH
REACTOME
REACT_243212
DSCAM interactions pathway
REACT_223082
Cell-Cell communication pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_25299
DSCAM interactions pathway
REACT_111155
Cell-Cell communication pathway
KEGG
INOH
PID NCI
era_genomic_pathway
Validated nuclear estrogen receptor alpha network
hnf3apathway
FOXA1 transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.328737
RefSeq NM_031174
OMIM
CCDS CCDS37415
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca