Version 5.4
Mus musculus Gene: Chrna1
Summary
InnateDB Gene IDBG-180256.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Chrna1
Gene Name cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle)
Synonyms Achr-1; Acra; AI385656; AI608266
Species Mus musculus
Ensembl Gene ENSMUSG00000027107
Encoded Proteins
IDBP-180258
cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an alpha subunit of the muscle-derived nicotinic acetylcholine receptor, a pentameric neurotransmitter receptor and member of the ligand-gated ion channel superfamily. The alpha subunit plays a role in substrate binding and channel gating. [provided by RefSeq, Nov 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:73563215-73580338
Strand Reverse strand
Band C3
Transcripts
ENSMUST00000028515 ENSMUSP00000028515
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004889 acetylcholine-activated cation-selective channel activity
GO:0005230 extracellular ligand-gated ion channel activity
GO:0005515 protein binding
GO:0015464 acetylcholine receptor activity
GO:0042166 acetylcholine binding
Biological Process
GO:0003009 skeletal muscle contraction
GO:0006810 transport
GO:0006811 ion transport
GO:0006812 cation transport
GO:0007274 neuromuscular synaptic transmission
GO:0007528 neuromuscular junction development
GO:0019228 neuronal action potential
GO:0034220 ion transmembrane transport
GO:0042391 regulation of membrane potential
GO:0046716 muscle cell cellular homeostasis
GO:0048630 skeletal muscle tissue growth
GO:0050881 musculoskeletal movement
GO:0050905 neuromuscular process
GO:0070050 neuron cellular homeostasis
Cellular Component
GO:0005886 plasma membrane
GO:0005892 acetylcholine-gated channel complex
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0031594 neuromuscular junction
GO:0045211 postsynaptic membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000138435
View Gene Order
ENSBTAG00000018253
Not yet available
Pathways
NETPATH
REACTOME
REACT_203664
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
REACT_198591
Presynaptic nicotinic acetylcholine receptors pathway
REACT_259290
Neuronal System pathway
REACT_198589
Activation of Nicotinic Acetylcholine Receptors pathway
REACT_198583
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors pathway
REACT_198587
Acetylcholine Binding And Downstream Events pathway
REACT_198586
Postsynaptic nicotinic acetylcholine receptors pathway
REACT_198585
Highly calcium permeable nicotinic acetylcholine receptors pathway
REACT_233318
Transmission across Chemical Synapses pathway
KEGG
mmu04080
Neuroactive ligand-receptor interaction pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_13685
Neuronal System pathway
REACT_22352
Highly calcium permeable nicotinic acetylcholine receptors pathway
REACT_22149
Postsynaptic nicotinic acetylcholine receptors pathway
REACT_22126
Activation of Nicotinic Acetylcholine Receptors pathway
REACT_22336
Presynaptic nicotinic acetylcholine receptors pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_22303
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors pathway
REACT_15370
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
REACT_15461
Acetylcholine Binding And Downstream Events pathway
REACT_217102
Presynaptic nicotinic acetylcholine receptors pathway
REACT_223058
Transmission across Chemical Synapses pathway
REACT_202705
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
REACT_216025
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors pathway
REACT_225032
Neuronal System pathway
REACT_202849
Activation of Nicotinic Acetylcholine Receptors pathway
REACT_226667
Postsynaptic nicotinic acetylcholine receptors pathway
REACT_219072
Highly calcium permeable nicotinic acetylcholine receptors pathway
REACT_214962
Acetylcholine Binding And Downstream Events pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
INOH
PID NCI
erbb2erbb3pathway
ErbB2/ErbB3 signaling events
botulinumtoxinpathway
Effects of Botulinum toxin
Cross-References
SwissProt P04756
TrEMBL A9XLH3 Q05A24
UniProt Splice Variant
Entrez Gene 11435
UniGene Mm.4583
RefSeq NM_007389
OMIM
CCDS CCDS16132
HPRD
IMGT
MGI ID MGI:87885
MGI Symbol Chrna1
EMBL AK029177 BC125439 BC137678 CH466519 EF520684 M17640 X03986
GenPept AAB53942 AAI25440 AAI37679 ABS82392 BAC26337 CAA27624 EDL27139
RNA Seq Atlas 11435

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca