Version 5.4
Homo sapiens Gene: PPP4R4
Summary
InnateDB Gene IDBG-18038.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPP4R4
Gene Name protein phosphatase 4, regulatory subunit 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000119698
Encoded Proteins
IDBP-18040
protein phosphatase 4, regulatory subunit 4
IDBP-18042
protein phosphatase 4, regulatory subunit 4
IDBP-602401
protein phosphatase 4, regulatory subunit 4
IDBP-599246
protein phosphatase 4, regulatory subunit 4
IDBP-598924
protein phosphatase 4, regulatory subunit 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a HEAT-like repeat-containing protein. The HEAT repeat is a tandemly repeated, 37-47 amino acid long module occurring in a number of cytoplasmic proteins. Arrays of HEAT repeats form a rod-like helical structure and appear to function as protein-protein interaction surfaces. The repeat-containing region of this protein has some similarity to the constant regulatory domain of the protein phosphatase 2A PR65/A subunit. The function of this particular gene product has not been determined. Alternative splicing has been observed for this gene and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:94146128-94279735
Strand Forward strand
Band q32.12
Transcripts
ENST00000304338 ENSP00000305924
ENST00000328839 ENSP00000330831
ENST00000556884 ENSP00000452121
ENST00000555690
ENST00000553661 ENSP00000451543
ENST00000556470 ENSP00000451556
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
GO:0019888 protein phosphatase regulator activity
Biological Process
GO:0032515 negative regulation of phosphoprotein phosphatase activity
GO:0080163 regulation of protein serine/threonine phosphatase activity
Cellular Component
GO:0005737 cytoplasm
GO:0008287 protein serine/threonine phosphatase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021209
View Gene Order
ENSBTAG00000009891
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.259599 Hs.641810
RefSeq NM_020958 NM_058237 XM_005267930 XM_005267931 XM_006720222 XM_006725168 XM_006725169 XM_006725170
HUGO
OMIM
CCDS CCDS9921 CCDS9922
HPRD 13878
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca