Version 5.4
Homo sapiens Gene: SLC25A22
Summary
InnateDB Gene IDBG-18043.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC25A22
Gene Name solute carrier family 25 (mitochondrial carrier: glutamate), member 22
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000177542
Encoded Proteins
IDBP-18045
solute carrier family 25 (mitochondrial carrier: glutamate), member 22
IDBP-360806
solute carrier family 25 (mitochondrial carrier: glutamate), member 22
IDBP-598718
solute carrier family 25 (mitochondrial carrier: glutamate), member 22
IDBP-591237
solute carrier family 25 (mitochondrial carrier: glutamate), member 22
IDBP-598757
solute carrier family 25 (mitochondrial carrier: glutamate), member 22
IDBP-587733
solute carrier family 25 (mitochondrial carrier: glutamate), member 22
IDBP-601278
solute carrier family 25 (mitochondrial carrier: glutamate), member 22
IDBP-590777
solute carrier family 25 (mitochondrial carrier: glutamate), member 22
IDBP-601304
solute carrier family 25 (mitochondrial carrier: glutamate), member 22
IDBP-596870
solute carrier family 25 (mitochondrial carrier: glutamate), member 22
IDBP-588714
solute carrier family 25 (mitochondrial carrier: glutamate), member 22
IDBP-599380
solute carrier family 25 (mitochondrial carrier: glutamate), member 22
IDBP-601465
solute carrier family 25 (mitochondrial carrier: glutamate), member 22
IDBP-588182
solute carrier family 25 (mitochondrial carrier: glutamate), member 22
IDBP-602425
solute carrier family 25 (mitochondrial carrier: glutamate), member 22
IDBP-592311
solute carrier family 25 (mitochondrial carrier: glutamate), member 22
IDBP-590792
solute carrier family 25 (mitochondrial carrier: glutamate), member 22
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a mitochondrial glutamate carrier. Mutations in this gene are associated with early infantile epileptic encephalopathy. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:790475-798316
Strand Reverse strand
Band p15.5
Transcripts
ENST00000320230 ENSP00000322020
ENST00000456706 ENSP00000392749
ENST00000481290 ENSP00000431829
ENST00000531214 ENSP00000437236
ENST00000531437 ENSP00000435862
ENST00000529351 ENSP00000432222
ENST00000533385 ENSP00000434287
ENST00000526152 ENSP00000436745
ENST00000528606 ENSP00000437045
ENST00000527734 ENSP00000433655
ENST00000527723 ENSP00000434479
ENST00000531514 ENSP00000433780
ENST00000528936 ENSP00000432817
ENST00000532484 ENSP00000431466
ENST00000524891
ENST00000529066 ENSP00000433028
ENST00000531534 ENSP00000435402
ENST00000532361
ENST00000527127
ENST00000525010
ENST00000532459
ENST00000525644
ENST00000530360 ENSP00000434850
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005313 L-glutamate transmembrane transporter activity
GO:0015293 symporter activity
Biological Process
GO:0006810 transport
GO:0015813 L-glutamate transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000019082
View Gene Order
ENSBTAG00000001229
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001191060 NM_001191061 NM_024698
HUGO
OMIM
CCDS CCDS7715
HPRD 15356
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca