Version 5.4
Mus musculus Gene: Tshb
Summary
InnateDB Gene IDBG-180457.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tshb
Gene Name thyroid stimulating hormone, beta subunit
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000027857
Encoded Proteins
IDBP-180459
thyroid stimulating hormone, beta subunit
IDBP-626297
thyroid stimulating hormone, beta subunit
IDBP-626298
thyroid stimulating hormone, beta subunit
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134200:
The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. Thyroid stimulating hormone functions in the control of thyroid structure and metabolism. The protein encoded by this gene is the beta subunit of thyroid stimulating hormone. Mutations in this gene result in congenital hypothyroidism.[provided by RefSeq, Nov 2009]
The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. Thyroid stimulating hormone functions in the control of thyroid structure and metabolism. The protein encoded by this gene is the beta subunit of thyroid stimulating hormone. Mutations in this gene are associated with congenital central and secondary hypothyroidism and Hashimoto\'s thyroiditis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:102777398-102782714
Strand Reverse strand
Band F2.2
Transcripts
ENSMUST00000029450 ENSMUSP00000029450
ENSMUST00000172026 ENSMUSP00000128440
ENSMUST00000170856 ENSMUSP00000127165
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005179 hormone activity
Biological Process
GO:0033189 response to vitamin A
GO:0043627 response to estrogen
GO:0051592 response to calcium ion
Cellular Component
GO:0005576 extracellular region
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000134200
View Gene Order
ENSBTAG00000006295
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04080
Neuroactive ligand-receptor interaction pathway
mmu05320
Autoimmune thyroid disease pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_23
TSH pathway
REACTOME
REACT_19327
G alpha (s) signalling events pathway
REACT_16942
Hormone ligand-binding receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_15398
Glycoprotein hormones pathway
REACT_15452
Peptide hormone biosynthesis pathway
REACT_15292
Thyroxine biosynthesis pathway
REACT_14797
Signaling by GPCR pathway
REACT_15513
Amine-derived hormones pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_17015
Metabolism of proteins pathway
REACT_13
Metabolism of amino acids and derivatives pathway
REACT_21340
GPCR ligand binding pathway
REACT_111217
Metabolism pathway
REACT_160078
Peptide hormone metabolism pathway
REACT_210701
Peptide hormone metabolism pathway
REACT_205369
Signaling by GPCR pathway
REACT_206547
G alpha (s) signalling events pathway
REACT_218655
Glycoprotein hormones pathway
REACT_214353
Signal Transduction pathway
REACT_220432
Peptide hormone biosynthesis pathway
REACT_213782
Metabolism of proteins pathway
REACT_214436
GPCR downstream signaling pathway
REACT_220217
GPCR ligand binding pathway
REACT_208412
Class A/1 (Rhodopsin-like receptors) pathway
REACT_210620
Hormone ligand-binding receptors pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
hsa05320
Autoimmune thyroid disease pathway
INOH
INOH website
GPCR signaling pathway
PID NCI
Cross-References
SwissProt
TrEMBL E9Q4F3
UniProt Splice Variant
Entrez Gene 22094
UniGene
RefSeq NM_001165939 NM_001165940 NM_009432 XM_006501300 XM_006501304
OMIM
CCDS CCDS17689
HPRD
IMGT
MGI ID MGI:98848
MGI Symbol Tshb
EMBL AC134871
GenPept
RNA Seq Atlas 22094

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca