Version 5.4
Mus musculus Gene: Lcp1
Summary
InnateDB Gene IDBG-180662.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lcp1
Gene Name lymphocyte cytosolic protein 1
Synonyms AW536232; D14Ertd310e; LCP-1; Pls2; pp65
Species Mus musculus
Ensembl Gene ENSMUSG00000021998
Encoded Proteins
IDBP-536148
lymphocyte cytosolic protein 1
IDBP-539291
lymphocyte cytosolic protein 1
IDBP-533882
lymphocyte cytosolic protein 1
IDBP-535610
lymphocyte cytosolic protein 1
IDBP-538785
lymphocyte cytosolic protein 1
IDBP-535579
lymphocyte cytosolic protein 1
IDBP-534781
lymphocyte cytosolic protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136167:
Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). However, L-plastin has been found in many types of malignant human cells of non-hemopoietic origin suggesting that its expression is induced accompanying tumorigenesis in solid tissues. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:75131101-75230842
Strand Forward strand
Band D3
Transcripts
ENSMUST00000143539 ENSMUSP00000118721
ENSMUST00000134114 ENSMUSP00000121376
ENSMUST00000124608
ENSMUST00000125833 ENSMUSP00000116033
ENSMUST00000124499 ENSMUSP00000121201
ENSMUST00000145303 ENSMUSP00000116271
ENSMUST00000122840 ENSMUSP00000117984
ENSMUST00000148609
ENSMUST00000149883
ENSMUST00000131802 ENSMUSP00000117137
ENSMUST00000130510
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0051015 actin filament binding
Biological Process
GO:0002286 T cell activation involved in immune response
GO:0007165 signal transduction
GO:0010737 protein kinase A signaling
GO:0016477 cell migration
GO:0031100 organ regeneration
GO:0033157 regulation of intracellular protein transport
GO:0051017 actin filament bundle assembly
Cellular Component
GO:0001725 stress fiber
GO:0001726 ruffle
GO:0001891 phagocytic cup
GO:0005578 proteinaceous extracellular matrix
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005884 actin filament
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0015629 actin cytoskeleton
GO:0030054 cell junction
GO:0030175 filopodium
GO:0032432 actin filament bundle
GO:0032587 ruffle membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000136167
View Gene Order
ENSBTAG00000007079
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_24
TSLP pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.467101 Mm.490125
RefSeq NM_001247984 NM_008879 XM_006518699 XM_006518700 XM_006518701 XM_006518702 XM_006518703 XM_006518704
OMIM
CCDS CCDS27276
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca