Version 5.4
Mus musculus Gene: Cacnb3
Summary
InnateDB Gene IDBG-180698.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cacnb3
Gene Name calcium channel, voltage-dependent, beta 3 subunit
Synonyms Beta3; Ca(v)beta3; CAB3; Cchb3
Species Mus musculus
Ensembl Gene ENSMUSG00000003352
Encoded Proteins
IDBP-180700
calcium channel, voltage-dependent, beta 3 subunit
IDBP-263004
calcium channel, voltage-dependent, beta 3 subunit
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000167535:
This gene encodes a regulatory beta subunit of the voltage-dependent calcium channel. Beta subunits are composed of five domains, which contribute to the regulation of surface expression and gating of calcium channels and may also play a role in the regulation of transcription factors and calcium transport. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:98632220-98644530
Strand Forward strand
Band F1
Transcripts
ENSMUST00000003442 ENSMUSP00000003442
ENSMUST00000109150 ENSMUSP00000104778
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005245 voltage-gated calcium channel activity
GO:0005515 protein binding
GO:0008331 high voltage-gated calcium channel activity
GO:0019901 protein kinase binding
Biological Process
GO:0006816 calcium ion transport
GO:0034765 regulation of ion transmembrane transport
GO:0050852 T cell receptor signaling pathway
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005891 voltage-gated calcium channel complex
GO:0016020 membrane
GO:0016324 apical plasma membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000167535
View Gene Order
ENSBTAG00000021808
Not yet available
Pathways
NETPATH
REACTOME
REACT_217323
Integration of energy metabolism pathway
REACT_236183
NCAM1 interactions pathway
REACT_188937
Metabolism pathway
REACT_263148
Regulation of insulin secretion pathway
REACT_261444
Axon guidance pathway
REACT_225645
Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels pathway
REACT_259290
Neuronal System pathway
REACT_188576
Developmental Biology pathway
REACT_233318
Transmission across Chemical Synapses pathway
REACT_237796
NCAM signaling for neurite out-growth pathway
KEGG
mmu04010
MAPK signaling pathway pathway
mmu04260
Cardiac muscle contraction pathway
mmu05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
mmu05410
Hypertrophic cardiomyopathy (HCM) pathway
mmu05414
Dilated cardiomyopathy pathway
INOH
INOH website
GPCR Dopamine D1like receptor signaling pathway pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_18339
Adrenaline,noradrenaline inhibits insulin secretion pathway
REACT_18325
Regulation of insulin secretion pathway
REACT_1505
Integration of energy metabolism pathway
REACT_18312
NCAM1 interactions pathway
REACT_18334
NCAM signaling for neurite out-growth pathway
REACT_111045
Developmental Biology pathway
REACT_13685
Neuronal System pathway
REACT_18266
Axon guidance pathway
REACT_13606
Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_111217
Metabolism pathway
REACT_220819
Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels pathway
REACT_209110
Regulation of insulin secretion pathway
REACT_217282
NCAM signaling for neurite out-growth pathway
REACT_202514
NCAM1 interactions pathway
REACT_217101
Integration of energy metabolism pathway
REACT_223058
Transmission across Chemical Synapses pathway
REACT_203140
Axon guidance pathway
REACT_225032
Neuronal System pathway
REACT_219139
Metabolism pathway
REACT_220844
Developmental Biology pathway
KEGG
hsa04010
MAPK signaling pathway pathway
hsa05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
hsa05410
Hypertrophic cardiomyopathy (HCM) pathway
hsa04260
Cardiac muscle contraction pathway
hsa05414
Dilated cardiomyopathy pathway
INOH
INOH website
GPCR Dopamine D1like receptor signaling pathway pathway
PID NCI
Cross-References
SwissProt
TrEMBL D3Z3Z3
UniProt Splice Variant
Entrez Gene 12297
UniGene Mm.3544
RefSeq NM_001044741 XM_006520360 XM_006520362 NM_007581 XM_006520359 XM_006520361 XM_006520366 XM_006520367 XM_006520368
OMIM
CCDS CCDS37192 CCDS27800
HPRD
IMGT
MGI ID MGI:103307
MGI Symbol Cacnb3
EMBL AC156543
GenPept
RNA Seq Atlas 12297

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca