Version 5.4
Mus musculus Gene: Sike1
Summary
InnateDB Gene IDBG-180777.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sike1
Gene Name suppressor of IKBKE 1
Synonyms 2810005O12Rik; 5730470L24Rik; AI450236; AI839862; Sike; Sikeb
Species Mus musculus
Ensembl Gene ENSMUSG00000027854
Encoded Proteins
IDBP-180779
suppressor of IKBKE 1
IDBP-400720
suppressor of IKBKE 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 16281057
[Homo sapiens] RP5-1000E10.4 (SIKE) is a physiological suppressor of IKKepsilon and TBK1 and plays an inhibitory role in virus- and TLR3-triggered IRF3 but not NF-kappaB activation pathways.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000052723:
SIKE interacts with IKK-epsilon (IKBKE; MIM 605048) and TBK1 (MIM 604834) and acts as a suppressor of TLR3 (MIM 603029) and virus-triggered interferon activation pathways (Huang et al., 2005 [PubMed 16281057]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:102995728-103003914
Strand Forward strand
Band F2.2
Transcripts
ENSMUST00000029447 ENSMUSP00000029447
ENSMUST00000119450 ENSMUSP00000112886
ENSMUST00000151065
ENSMUST00000137332
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 25 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0008150 biological_process
Cellular Component
GO:0005737 cytoplasm
GO:0005925 focal adhesion
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000052723
View Gene Order
ENSBTAG00000015977
Not yet available
Pathways
NETPATH
REACTOME
REACT_239142
Innate Immune System pathway
REACT_230745
Immune System pathway
REACT_198521
TRAF6 mediated IRF7 activation pathway
REACT_219118
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
REACT_231481
TRAF3-dependent IRF activation pathway pathway
KEGG
mmu04622
RIG-I-like receptor signaling pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_24938
TRAF6 mediated IRF7 activation pathway
REACT_25026
TRAF3-dependent IRF activation pathway pathway
REACT_25359
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
REACT_6802
Innate Immune System pathway
REACT_6900
Immune System pathway
REACT_221101
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
REACT_213138
Immune System pathway
REACT_205128
TRAF3-dependent IRF activation pathway pathway
REACT_218986
TRAF6 mediated IRF7 activation pathway
REACT_216714
Innate Immune System pathway
KEGG
hsa04622
RIG-I-like receptor signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.208619 Mm.467753
RefSeq NM_025679
OMIM
CCDS CCDS17690
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca