Version 5.4
Homo sapiens Gene: DAPK3
Summary
InnateDB Gene IDBG-18095.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DAPK3
Gene Name death-associated protein kinase 3
Synonyms DLK; ZIP; ZIPK
Species Homo sapiens
Ensembl Gene ENSG00000167657
Encoded Proteins
IDBP-18097
death-associated protein kinase 3
IDBP-603761
death-associated protein kinase 3
IDBP-759791
IDBP-765842
IDBP-762174
IDBP-763668
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009] Death-associated protein kinase 3 (DAPK3) induces morphological changes in apoptosis when overexpressed in mammalian cells. These results suggest that DAPK3 may play a role in the induction of apoptosis. [provided by RefSeq, Jul 2008]
Death-associated protein kinase 3 (DAPK3) induces morphological changes in apoptosis when overexpressed in mammalian cells. These results suggest that DAPK3 may play a role in the induction of apoptosis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:3958453-3971123
Strand Reverse strand
Band p13.3
Transcripts
ENST00000301264 ENSP00000301264
ENST00000545797 ENSP00000442973
ENST00000596311 ENSP00000471154
ENST00000593844 ENSP00000470115
ENST00000594894 ENSP00000470168
ENST00000595279
ENST00000601824 ENSP00000472988
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 31 [view]
Protein-Protein 31 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004683 calmodulin-dependent protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043522 leucine zipper domain binding
Biological Process
GO:0000910 cytokinesis
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0006940 regulation of smooth muscle contraction
GO:0007088 regulation of mitosis
GO:0009103 lipopolysaccharide biosynthetic process
GO:0010506 regulation of autophagy
GO:0016568 chromatin modification
GO:0017148 negative regulation of translation
GO:0030182 neuron differentiation
GO:0035556 intracellular signal transduction
GO:0042981 regulation of apoptotic process
GO:0046777 protein autophosphorylation
GO:0071346 cellular response to interferon-gamma
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:0097190 apoptotic signaling pathway
GO:2000145 regulation of cell motility
GO:2000249 regulation of actin cytoskeleton reorganization
GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
Cellular Component
GO:0000775 chromosome, centromeric region
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
GO:0016020 membrane
GO:0016605 PML body
GO:0045121 membrane raft
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000034974
View Gene Order
ENSBTAG00000020417
Not yet available
Pathways
NETPATH
NetPath_2
AndrogenReceptor pathway
REACTOME
REACT_22128
Role of DCC in regulating apoptosis pathway
REACT_578
Apoptosis pathway
REACT_13648
Regulation of Apoptosis pathway
KEGG
hsa05219
Bladder cancer pathway
hsa05200
Pathways in cancer pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL M0QYW5 M0R0D0
UniProt Splice Variant
Entrez Gene 693222
UniGene Hs.631844
RefSeq NM_001348 XM_005259508
HUGO HGNC:2676
OMIM 603289
CCDS CCDS12116
HPRD 04478
IMGT
EMBL AC011488
GenPept
RNA Seq Atlas 1613 693222

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca