Version 5.4
Mus musculus Gene: Tie1
Summary
InnateDB Gene IDBG-181621.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tie1
Gene Name tyrosine kinase with immunoglobulin-like and EGF-like domains 1
Synonyms D430008P04Rik; TIE; tie-1
Species Mus musculus
Ensembl Gene ENSMUSG00000033191
Encoded Proteins
IDBP-181623
tyrosine kinase with immunoglobulin-like and EGF-like domains 1
IDBP-789247
tyrosine kinase with immunoglobulin-like and EGF-like domains 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000066056:
This gene encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:118471191-118490061
Strand Reverse strand
Band D2.1
Transcripts
ENSMUST00000047421 ENSMUSP00000037129
ENSMUST00000153286
ENSMUST00000184261 ENSMUSP00000139279
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0001525 angiogenesis
GO:0001568 blood vessel development
GO:0001570 vasculogenesis
GO:0001701 in utero embryonic development
GO:0006468 protein phosphorylation
GO:0016525 negative regulation of angiogenesis
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0030336 negative regulation of cell migration
GO:0032526 response to retinoic acid
GO:0045026 plasma membrane fusion
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000066056
View Gene Order
ENSBTAG00000003777
Not yet available
Cross-References
SwissProt
TrEMBL Q6PAP2
UniProt Splice Variant
Entrez Gene 21846
UniGene
RefSeq NM_011587
OMIM
CCDS CCDS18553
HPRD
IMGT
MGI ID MGI:99906
MGI Symbol Tie1
EMBL AL627212 BC057004 BC060182
GenPept AAH57004 AAH60182
RNA Seq Atlas 21846

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca