Version 5.4
Mus musculus Gene: Hipk1
Summary
InnateDB Gene IDBG-181648.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hipk1
Gene Name homeodomain interacting protein kinase 1
Synonyms 1110062K04Rik; Myak
Species Mus musculus
Ensembl Gene ENSMUSG00000008730
Encoded Proteins
IDBP-181650
homeodomain interacting protein kinase 1
IDBP-267919
homeodomain interacting protein kinase 1
IDBP-400680
homeodomain interacting protein kinase 1
IDBP-400678
homeodomain interacting protein kinase 1
IDBP-536170
homeodomain interacting protein kinase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163349:
The protein encoded by this gene belongs to the Ser/Thr family of protein kinases and HIPK subfamily. It phosphorylates homeodomain transcription factors and may also function as a co-repressor for homeodomain transcription factors. Alternative splicing results in four transcript variants encoding four distinct isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:103739815-103791563
Strand Reverse strand
Band F2.2
Transcripts
ENSMUST00000029438 ENSMUSP00000029438
ENSMUST00000106845 ENSMUSP00000102458
ENSMUST00000118317 ENSMUSP00000113998
ENSMUST00000121324 ENSMUSP00000114065
ENSMUST00000137078 ENSMUSP00000120396
ENSMUST00000126351
ENSMUST00000135634
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003714 transcription corepressor activity
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0016773 phosphotransferase activity, alcohol group as acceptor
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0007224 smoothened signaling pathway
GO:0008284 positive regulation of cell proliferation
GO:0009103 lipopolysaccharide biosynthetic process
GO:0009952 anterior/posterior pattern specification
GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway
GO:0010842 retina layer formation
GO:0016926 protein desumoylation
GO:0030182 neuron differentiation
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043388 positive regulation of DNA binding
GO:0048596 embryonic camera-type eye morphogenesis
GO:0060059 embryonic retina morphogenesis in camera-type eye
GO:0060235 lens induction in camera-type eye
GO:0061072 iris morphogenesis
GO:0072577 endothelial cell apoptotic process
GO:0097191 extrinsic apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0016605 PML body
GO:0016607 nuclear speck
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000163349
View Gene Order
ENSBTAG00000011322
Not yet available
Pathways
NETPATH
REACTOME
REACT_233572
Gene Expression pathway
REACT_196516
YAP1- and WWTR1 (TAZ)-stimulated gene expression pathway
REACT_206529
Generic Transcription Pathway pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_118713
YAP1- and WWTR1 (TAZ)-stimulated gene expression pathway
REACT_12627
Generic Transcription Pathway pathway
REACT_71
Gene Expression pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL A0S0D7 A0S0D9 A0S0L0 A0S0L1 A0S0L4 A0S0L5 E9Q1Q8
UniProt Splice Variant
Entrez Gene 15257
UniGene Mm.20827 Mm.406617 Mm.413631 Mm.416552 Mm.475514
RefSeq NM_010432 XM_006501032 XM_006501033 XM_006535888 XM_006535889
OMIM
CCDS CCDS38576
HPRD
IMGT
MGI ID MGI:1314873
MGI Symbol Hipk1
EMBL AC132567 DQ275151 DQ275153 DQ279084 DQ279085 DQ279088 DQ279089
GenPept ABB90240 ABB90241 ABB90244 ABB90245 ABB92153 ABB92155
RNA Seq Atlas 15257

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca