InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PIAS4

Summary

InnateDB Gene

IDBG-18183.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PIAS4

Gene Name

protein inhibitor of activated STAT, 4

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000105229

Encoded Proteins

IDBP-18185

protein inhibitor of activated STAT, 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21199872

PIAS4 is a member of the Protein Inhibitor of Activated STAT protein family, which regulate innate immune response by controlling transcription induced by TLR, RLR and JAK/STAT signalling pathways. PIAS4 specifically negatively regulate both IFN transcription and IFN stimulated gene expression through multiple mechanisms utilizing the function of different domains.

InnateDB Annotation from Orthologs

Summary

PMID 21199872

[Mus musculus] Pias4 is a member of the Protein Inhibitor of Activated STAT protein family, which regulate innate immune response by controlling transcription induced by Tlr, Rlr and Jak/Stat signalling pathways. Pias4 specifically negatively regulate both Ifn transcription and Ifn stimulated gene expression through multiple mechanisms utilizing the function of different domains.

Entrez Gene

Summary

Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:4007646-4039386

Strand

Forward strand

Band

p13.3

Transcripts

ENST00000262971	ENSP00000262971
ENST00000593518
ENST00000596144
ENST00000600566
ENST00000601439
ENST00000599999

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 136 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	136 [view]
Protein-Protein	135 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0019789	SUMO ligase activity
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0016055	Wnt signaling pathway
GO:0016925	protein sumoylation
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0033235	positive regulation of protein sumoylation
GO:0045087	innate immune response (InnateDB)
GO:0045892	negative regulation of transcription, DNA-templated
GO:1902174	positive regulation of keratinocyte apoptotic process
GO:1902231	positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016363	nuclear matrix
GO:0016605	PML body

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000004934

View Gene Order

ENSBTAG00000000753

Not yet available

Pathways

NETPATH

NetPath_2

AndrogenReceptor pathway

REACTOME

KEGG

hsa04120

Ubiquitin mediated proteolysis pathway

hsa04630

Jak-STAT signaling pathway pathway

INOH

PID NCI

ar_pathway

Coregulation of Androgen receptor activity

smad2_3nuclearpathway

Regulation of nuclear SMAD2/3 signaling

smad2_3pathway

Regulation of cytoplasmic and nuclear SMAD2/3 signaling

ifngpathway

IFN-gamma pathway

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.105779 Hs.619701

RefSeq

NM_015897

HUGO

OMIM

CCDS

CCDS12118

HPRD

06910

IMGT

EMBL

GenPept

RNA Seq Atlas