InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Prdx3

Summary

InnateDB Gene

IDBG-181859.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Prdx3

Gene Name

peroxiredoxin 3

Synonyms

Aop1; AW822249; D0Tohi1; Ef2l; Mer5; Prx3; SP22; TDXM

Species

Mus musculus

Ensembl Gene

ENSMUSG00000024997

Encoded Proteins

IDBP-181861

peroxiredoxin 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000165672:
This gene encodes a protein with antioxidant function and is localized in the mitochondrion. This gene shows significant nucleotide sequence similarity to the gene coding for the C22 subunit of Salmonella typhimurium alkylhydroperoxide reductase. Expression of this gene product in E. coli deficient in the C22-subunit gene rescued resistance of the bacteria to alkylhydroperoxide. The human and mouse genes are highly conserved, and they map to the regions syntenic between mouse and human chromosomes. Sequence comparisons with recently cloned mammalian homologues suggest that these genes consist of a family that is responsible for regulation of cellular proliferation, differentiation, and antioxidant functions. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
This gene encodes a mitochondrial protein with antioxidant function. The protein is similar to the C22 subunit of Salmonella typhimurium alkylhydroperoxide reductase, and it can rescue bacterial resistance to alkylhydroperoxide in E. coli that lack the C22 subunit. The human and mouse genes are highly conserved, and they map to the regions syntenic between mouse and human chromosomes. Sequence comparisons with recently cloned mammalian homologs suggest that these genes consist of a family that is responsible for the regulation of cellular proliferation, differentiation and antioxidant functions. This family member can protect cells from oxidative stress, and it can promote cell survival in prostate cancer. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1, 3, 13 and 22. [provided by RefSeq, Oct 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:60864051-60874556

Strand

Reverse strand

Band

Transcripts

ENSMUST00000025961

ENSMUSP00000025961

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	31 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004601	peroxidase activity
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0008379	thioredoxin peroxidase activity
GO:0016209	antioxidant activity
GO:0016491	oxidoreductase activity
GO:0019900	kinase binding
GO:0019901	protein kinase binding
GO:0042802	identical protein binding
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0051920	peroxiredoxin activity

Biological Process

GO:0001893	maternal placenta development
GO:0006979	response to oxidative stress
GO:0007005	mitochondrion organization
GO:0008284	positive regulation of cell proliferation
GO:0018171	peptidyl-cysteine oxidation
GO:0030099	myeloid cell differentiation
GO:0032496	response to lipopolysaccharide
GO:0033673	negative regulation of kinase activity
GO:0034599	cellular response to oxidative stress
GO:0034614	cellular response to reactive oxygen species
GO:0042542	response to hydrogen peroxide
GO:0042744	hydrogen peroxide catabolic process
GO:0043066	negative regulation of apoptotic process
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051881	regulation of mitochondrial membrane potential
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005769	early endosome
GO:0005829	cytosol
GO:0008385	IkappaB kinase complex
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000165672

View Gene Order

ENSBTAG00000008731

Not yet available

Pathways

NETPATH

REACTOME

REACT_188957

Cellular responses to stress pathway

REACT_189141

Detoxification of Reactive Oxygen Species pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_120956

Cellular responses to stress pathway

REACT_172715

Detoxification of Reactive Oxygen Species pathway

REACT_206069

Cellular responses to stress pathway

REACT_204534

Detoxification of Reactive Oxygen Species pathway

KEGG

INOH

PID NCI

myc_activpathway

Validated targets of C-MYC transcriptional activation

Cross-References

SwissProt

P20108

TrEMBL

Q8K4K8

UniProt Splice Variant

Entrez Gene

11757

UniGene

Mm.29821 Mm.395088

RefSeq

NM_007452

OMIM

CCDS

CCDS29944

HPRD

IMGT

MGI ID

MGI:88034

MGI Symbol

Prdx3

EMBL

AF211933 AF211934 AF211935 AF211936 AF211937 AF211938 AF333976 AK002448 BC005626 M28723

GenPept

AAA39524 AAF63705 AAH05626 AAM74564 BAB22108

RNA Seq Atlas

11757