Version 5.4
Mus musculus Gene: Herpud1
Summary
InnateDB Gene IDBG-182026.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Herpud1
Gene Name homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
Synonyms Herp; Mifl; SUP
Species Mus musculus
Ensembl Gene ENSMUSG00000031770
Encoded Proteins
IDBP-182028
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
IDBP-536258
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000051108:
The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers the ER stress response. This response includes the inhibition of translation to prevent further accumulation of unfolded proteins, the increased expression of proteins involved in polypeptide folding, known as the unfolded protein response (UPR), and the destruction of misfolded proteins by the ER-associated protein degradation (ERAD) system. This gene may play a role in both UPR and ERAD. Its expression is induced by UPR and it has an ER stress response element in its promoter region while the encoded protein has an N-terminal ubiquitin-like domain which may interact with the ERAD system. This protein has been shown to interact with presenilin proteins and to increase the level of amyloid-beta protein following its overexpression. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms. The full-length nature of all transcript variants has not been determined. [provided by RefSeq, Jan 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:94386438-94395377
Strand Forward strand
Band C5
Transcripts
ENSMUST00000034220 ENSMUSP00000034220
ENSMUST00000161576 ENSMUSP00000124201
ENSMUST00000161085
ENSMUST00000159450
ENSMUST00000160866
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 26 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006874 cellular calcium ion homeostasis
GO:0006986 response to unfolded protein
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0031396 regulation of protein ubiquitination
GO:0032092 positive regulation of protein binding
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000051108
View Gene Order
ENSBTAG00000016896
Not yet available
Pathways
NETPATH
REACTOME
REACT_239697
Unfolded Protein Response (UPR) pathway
REACT_247926
Metabolism of proteins pathway
REACT_243361
PERK regulates gene expression pathway
REACT_90370
ATF4 activates genes pathway
KEGG
mmu04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_18355
ATF4 activates genes pathway
REACT_18277
PERK regulates gene expression pathway
REACT_18356
Unfolded Protein Response (UPR) pathway
REACT_17015
Metabolism of proteins pathway
KEGG
hsa04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Cross-References
SwissProt Q9JJK5
TrEMBL Q3TMN9 Q6A0E4 Q8C4N0 Q921B3
UniProt Splice Variant
Entrez Gene 64209
UniGene Mm.29151 Mm.395086
RefSeq NM_022331 XM_006531260
OMIM
CCDS CCDS22541
HPRD
IMGT
MGI ID MGI:1927406
MGI Symbol Herpud1
EMBL AB034991 AC128663 AJ320519 AK081688 AK159500 AK165832 AK172874 CH466525
GenPept BAB07892 BAC38293 BAD32152 BAE35133 BAE38402 CAC48391 EDL11127
RNA Seq Atlas 64209

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca