Mus musculus Gene: Hsp90b1 | |||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||
InnateDB Gene | IDBG-182078.6 | ||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||
Gene Symbol | Hsp90b1 | ||||||||||||||||||||||||
Gene Name | heat shock protein 90, beta (Grp94), member 1 | ||||||||||||||||||||||||
Synonyms | endoplasmin; ERp99; gp96; GRP94; TA-3; Targ2; Tra-1; Tra1 | ||||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000020048 | ||||||||||||||||||||||||
Encoded Proteins |
heat shock protein 90, beta (Grp94), member 1
heat shock protein 90, beta (Grp94), member 1
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Protein Structure | |||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||
InnateDB Annotation | |||||||||||||||||||||||||
Summary |
Hsp90b1 on the surface of polymorphonuclear leukocytes (PMNs) serves as a receptor for Escherichia coli K1 (EC-K1) entry. EC-K1 exploits surface-expressed Hsp90b1 in PMNs to prevent oxidative burst for the onset of neonatal meningitis.
Hsp90b1 is an essential endoplasmic reticulum chaperone protein for Toll-like receptors and integrins.
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InnateDB Annotation from Orthologs | |||||||||||||||||||||||||
Summary |
[Homo sapiens] HSP90B1 amplifies innate and adaptive immune responses via interaction with TLR2 and TLR4 ligands.
[Homo sapiens] Absence of HSP90B1 results in a defect in the formation of some cell surface receptors including Toll-like receptors (TLRs) which, as a result, are retained intracellularly.
[Homo sapiens] HSP90B1 is an endoplasmic reticulum master chaperone for multiple TLRs and is also essential for expression of multiple hematopoietic system-specific integrins.
[Homo sapiens] HSP90B1, an endoplasmic reticulum chaperone, is required in vesicular stomatitis virus (VSV) infection and in innate immunity via Toll-like receptors (TLRs). TLR-mediated immunity maintains the broad host range of the envelope glycoprotein of VSV (VSV-G) by positively selecting for the ubiquitous expression of HSP90B1.
[Homo sapiens] HSP90B1 chaperones multiple Toll-like receptors (TLRs), but not TLR3, in a manner that is dependent on another endoplasmic reticulum (ER) luminal protein, CNPY3.
[Homo sapiens] HSP90B1 on the surface of polymorphonuclear leukocytes (PMNs) serves as a receptor for Escherichia coli K1 (EC-K1) entry into the cell. EC-K1 exploits surface-expressed HSP90B1 in PMNs to prevent oxidative burst for the onset of neonatal meningitis. (Demonstrated in mice)
[Homo sapiens] HSP90B1 is an essential endoplasmic reticulum chaperone protein for Toll-like receptors (TLR) and integrins. (Demonstrated in mice)
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Entrez Gene | |||||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000166598:
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009] This gene encodes a member of a family of adenosine triphosphate(ATP)-metabolizing molecular chaperones with roles in stabilizing and folding other proteins. The encoded protein is localized to melanosomes and the endoplasmic reticulum. Expression of this protein is associated with a variety of pathogenic states, including tumor formation. There is a microRNA gene located within the 5' exon of this gene. There are pseudogenes for this gene on chromosomes 1 and 15. [provided by RefSeq, Aug 2012] This gene encodes a member of a family of adenosine triphosphate(ATP)-metabolizing molecular chaperones with roles in stabilizing and folding other proteins. The encoded protein is localized to melanosomes and the endoplasmic reticulum. Expression of this protein is associated with a variety of pathogenic states, including tumor formation. There is a microRNA gene located within the 5\' exon of this gene. There are pseudogenes for this gene on chromosomes 1 and 15. [provided by RefSeq, Aug 2012] |
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Gene Information | |||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||
Genomic Location | Chromosome 10:86690209-86705509 | ||||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||||
Band | C1 | ||||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 71 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||||
REACTOME |
Innate Immune System pathway
ATF6-alpha activates chaperone genes pathway
Trafficking and processing of endosomal TLR pathway
Unfolded Protein Response (UPR) pathway
Immune System pathway
Metabolism of proteins pathway
Binding and Uptake of Ligands by Scavenger Receptors pathway
Scavenging by Class A Receptors pathway
ATF6-alpha activates chaperones pathway
Toll-Like Receptors Cascades pathway
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KEGG |
Prostate cancer pathway
Pathways in cancer pathway
NOD-like receptor signaling pathway pathway
Protein processing in endoplasmic reticulum pathway
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INOH | |||||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||
NETPATH |
AndrogenReceptor pathway
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REACTOME |
Trafficking and processing of endosomal TLR pathway
ATF6-alpha activates chaperone genes pathway
ATF6-alpha activates chaperones pathway
Unfolded Protein Response (UPR) pathway
Innate Immune System pathway
Toll-Like Receptors Cascades pathway
Binding and Uptake of Ligands by Scavenger Receptors pathway
Scavenging by Class A Receptors pathway
Metabolism of proteins pathway
Immune System pathway
Trafficking and processing of endosomal TLR pathway
Immune System pathway
ATF6-alpha activates chaperone genes pathway
Scavenging by Class A Receptors pathway
Toll-Like Receptors Cascades pathway
Binding and Uptake of Ligands by Scavenger Receptors pathway
Metabolism of proteins pathway
Unfolded Protein Response (UPR) pathway
Innate Immune System pathway
ATF6-alpha activates chaperones pathway
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KEGG |
Prostate cancer pathway
Pathways in cancer pathway
NOD-like receptor signaling pathway pathway
Protein processing in endoplasmic reticulum pathway
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INOH | |||||||||||||||||||||||||
PID NCI |
IL6-mediated signaling events
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Cross-References | |||||||||||||||||||||||||
SwissProt | P08113 | ||||||||||||||||||||||||
TrEMBL | Q3UAD6 Q8C2R2 Q9CW12 | ||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||
Entrez Gene | 22027 | ||||||||||||||||||||||||
UniGene | Mm.87773 | ||||||||||||||||||||||||
RefSeq | NM_011631 | ||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||
CCDS | CCDS36019 | ||||||||||||||||||||||||
HPRD | |||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||
MGI ID | MGI:98817 | ||||||||||||||||||||||||
MGI Symbol | Hsp90b1 | ||||||||||||||||||||||||
EMBL | AK005469 AK088148 AK146885 AK151413 AK153550 AK159974 AK165975 AK168952 AK169090 CH466539 J03297 M16370 M29652 | ||||||||||||||||||||||||
GenPept | AAA37573 AAA37743 AAA40023 BAB24059 BAC40172 BAE27505 BAE30378 BAE32087 BAE35526 BAE38494 BAE40758 BAE40874 EDL21440 | ||||||||||||||||||||||||
RNA Seq Atlas | 22027 | ||||||||||||||||||||||||