InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Gabbr1

Summary

InnateDB Gene

IDBG-182141.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gabbr1

Gene Name

gamma-aminobutyric acid (GABA) B receptor, 1

Synonyms

bM573K1.1; GABAB1; GABAbR1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000024462

Encoded Proteins

IDBP-182143

gamma-aminobutyric acid (GABA) B receptor, 1

IDBP-622311

gamma-aminobutyric acid (GABA) B receptor, 1

IDBP-622317

gamma-aminobutyric acid (GABA) B receptor, 1

IDBP-622319

gamma-aminobutyric acid (GABA) B receptor, 1

IDBP-622320

gamma-aminobutyric acid (GABA) B receptor, 1

IDBP-622322

gamma-aminobutyric acid (GABA) B receptor, 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000204681:
Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system. GABA exerts its effects through ionotropic [GABA(A/C)] receptors, to produce fast synaptic inhibition, and metabotropic [GABA(B)] receptors, to produce slow, prolonged inhibitory signals. The GABA(B) receptor consists of a heterodimer of two related 7-transmembrane receptors, GABA(B) receptor 1 and GABA(B) receptor 2. The GABA(B) receptor 1 gene is mapped to chromosome 6p21.3 within the HLA class I region close to the HLA-F gene. Susceptibility loci for multiple sclerosis, epilepsy, and schizophrenia have also been mapped in this region. Alternative splicing of this gene generates multiple transcript variants. [provided by RefSeq, Jun 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:37045966-37075067

Strand

Forward strand

Band

Transcripts

ENSMUST00000025338	ENSMUSP00000025338
ENSMUST00000173823	ENSMUSP00000133797
ENSMUST00000174456	ENSMUSP00000134409
ENSMUST00000174826
ENSMUST00000172789	ENSMUSP00000134580
ENSMUST00000173564
ENSMUST00000172792	ENSMUSP00000134268
ENSMUST00000174347	ENSMUSP00000134346
ENSMUST00000174866
ENSMUST00000174181
ENSMUST00000174071

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004965	G-protein coupled GABA receptor activity
GO:0005515	protein binding

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007214	gamma-aminobutyric acid signaling pathway

Cellular Component

GO:0005737	cytoplasm
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0030425	dendrite
GO:0038037	G-protein coupled receptor dimeric complex
GO:0038039	G-protein coupled receptor heterodimeric complex
GO:0042734	presynaptic membrane
GO:0045211	postsynaptic membrane