Version 5.4
Mus musculus Gene: Nlrc5
Summary
InnateDB Gene IDBG-182231.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nlrc5
Gene Name NLR family, CARD domain containing 5
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000074151
Encoded Proteins
IDBP-789051
NLR family, CARD domain containing 5
IDBP-789053
NLR family, CARD domain containing 5
IDBP-789052
NLR family, CARD domain containing 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 26620909
The reversible ubiquitin editing of Nlrc5 determines Nlrc5â?? Ikbkb interaction dynamics and plays a crucial role in precisely regulating NFκB signalling
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 8:94472763-94527272
Strand Forward strand
Band C5
Transcripts
ENSMUST00000053085 ENSMUSP00000138322
ENSMUST00000098489 ENSMUSP00000138409
ENSMUST00000137032
ENSMUST00000182409
ENSMUST00000183132 ENSMUSP00000138166
ENSMUST00000183287
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0005524 ATP binding
Biological Process
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0043549 regulation of kinase activity
GO:0045087 innate immune response (InnateDB)
GO:0045345 positive regulation of MHC class I biosynthetic process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051607 defense response to virus
GO:0060335 positive regulation of interferon-gamma-mediated signaling pathway
GO:0060339 negative regulation of type I interferon-mediated signaling pathway
GO:0060340 positive regulation of type I interferon-mediated signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_239142
Innate Immune System pathway
REACT_198532
Negative regulators of RIG-I/MDA5 signaling pathway
REACT_230745
Immune System pathway
REACT_219118
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001033207 XM_006531162 XM_006531163 XM_006531166
OMIM
CCDS CCDS59741
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca