Version 5.4
Mus musculus Gene: Sh3kbp1
Summary
InnateDB Gene IDBG-182475.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sh3kbp1
Gene Name SH3-domain kinase binding protein 1
Synonyms 1200007H22Rik; 1700125L08Rik; 5830464D22Rik; AI447724; IN85; Ruk; Seta
Species Mus musculus
Ensembl Gene ENSMUSG00000040990
Encoded Proteins
IDBP-182477
SH3-domain kinase binding protein 1
IDBP-182479
SH3-domain kinase binding protein 1
IDBP-255967
SH3-domain kinase binding protein 1
IDBP-255971
SH3-domain kinase binding protein 1
IDBP-255973
SH3-domain kinase binding protein 1
IDBP-542559
SH3-domain kinase binding protein 1
IDBP-542555
SH3-domain kinase binding protein 1
IDBP-542820
SH3-domain kinase binding protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000147010:
This gene encodes an adapter protein that contains three N-terminal Src homology domains, a proline rich region and a C-terminal coiled-coil domain. The encoded protein facilitates protein-protein interactions and has been implicated in numerous cellular processes including apoptosis, cytoskeletal rearrangement, cell adhesion and in the regulation of clathrin-dependent endocytosis. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome X:159627272-159978069
Strand Forward strand
Band F4
Transcripts
ENSMUST00000073094 ENSMUSP00000072840
ENSMUST00000080394 ENSMUSP00000079257
ENSMUST00000112456 ENSMUSP00000108075
ENSMUST00000112453 ENSMUSP00000108072
ENSMUST00000112451 ENSMUSP00000108070
ENSMUST00000112447
ENSMUST00000150433
ENSMUST00000123433 ENSMUSP00000114799
ENSMUST00000141354 ENSMUSP00000114262
ENSMUST00000152426 ENSMUSP00000117618
ENSMUST00000134062
ENSMUST00000128185
ENSMUST00000142426
ENSMUST00000130987
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 178 interaction(s) predicted by orthology.
Experimentally validated
Total 19 [view]
Protein-Protein 19 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 178 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0017124 SH3 domain binding
Biological Process
GO:0006897 endocytosis
GO:0006915 apoptotic process
GO:0007010 cytoskeleton organization
GO:0008360 regulation of cell shape
GO:0016477 cell migration
Cellular Component
GO:0005856 cytoskeleton
GO:0005911 cell-cell junction
GO:0005925 focal adhesion
GO:0030659 cytoplasmic vesicle membrane
GO:0043005 neuron projection
GO:0045202 synapse
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000147010
View Gene Order
ENSBTAG00000003727
Not yet available
Pathways
NETPATH
REACTOME
REACT_203917
EGFR downregulation pathway
REACT_188199
Signaling by the B Cell Receptor (BCR) pathway
REACT_188194
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers pathway
REACT_189085
Disease pathway
REACT_230745
Immune System pathway
REACT_242976
Signaling by EGFR pathway
REACT_229531
Adaptive Immune System pathway
REACT_188257
Signal Transduction pathway
REACT_188180
Signaling by EGFR in Cancer pathway
KEGG
mmu04144
Endocytosis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
NetPath_6
KitReceptor pathway
REACTOME
REACT_118700
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers pathway
REACT_12484
EGFR downregulation pathway
REACT_9417
Signaling by EGFR pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_111102
Signal Transduction pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_118773
Signaling by the B Cell Receptor (BCR) pathway
REACT_116125
Disease pathway
KEGG
hsa04144
Endocytosis pathway
INOH
PID NCI
met_pathway
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
erbb1_internalization_pathway
Internalization of ErbB1
Cross-References
SwissProt Q8R550
TrEMBL Q3TSX2 Q3TT90
UniProt Splice Variant
Entrez Gene 58194
UniGene Mm.286495 Mm.386582
RefSeq NM_001135727 NM_001135728 NM_021389 XM_006528929
OMIM
CCDS CCDS41194 CCDS53234 CCDS53235
HPRD
IMGT
MGI ID MGI:1889583
MGI Symbol Sh3kbp1
EMBL AF243508 AF472304 AF472305 AF472306 AF472307 AF472308 AF472309 AF472310 AF472311 AF472312 AF472313 AF472314 AF472315 AF472316 AF472317 AF472318 AF472319 AF472320 AF472321 AF472322 AF472323 AF472324 AF472325 AF472326 AF472327 AI428677 AK004636 AK020782 AK038540 AK049182 AK142295 AK161512 AK161735 AL929452
GenPept AAF68439 AAL82456 AAL82457 AAL82458 AAL82459 AAL82460 AAL82461 AAL82462 BAB23427 BAB32209 BAC30033 BAC33592 BAE25017 BAE36435 BAE36553 CAM21669 CAM21670
RNA Seq Atlas 58194

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca