InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ATP2A3

Summary

InnateDB Gene

IDBG-18252.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATP2A3

Gene Name

ATPase, Ca++ transporting, ubiquitous

Synonyms

SERCA3

Species

Homo sapiens

Ensembl Gene

ENSG00000074370

Encoded Proteins

IDBP-18254

ATPase, Ca++ transporting, ubiquitous

IDBP-18256

ATPase, Ca++ transporting, ubiquitous

IDBP-18258

ATPase, Ca++ transporting, ubiquitous

IDBP-236181

ATPase, Ca++ transporting, ubiquitous

IDBP-236183

ATPase, Ca++ transporting, ubiquitous

IDBP-236187

ATPase, Ca++ transporting, ubiquitous

IDBP-761505

IDBP-758362

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in calcium sequestration associated with muscular excitation and contraction. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:3923870-3964464

Strand

Reverse strand

Band

p13.2

Transcripts

ENST00000359983	ENSP00000353072
ENST00000352011	ENSP00000301387
ENST00000309890	ENSP00000312577
ENST00000397043	ENSP00000380236
ENST00000397041	ENSP00000380234
ENST00000397035	ENSP00000380229
ENST00000572176
ENST00000576957
ENST00000574999
ENST00000574202
ENST00000570773
ENST00000570845	ENSP00000461480
ENST00000571245
ENST00000572116	ENSP00000458865
ENST00000572694

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005388	calcium-transporting ATPase activity
GO:0005524	ATP binding
GO:0019829	cation-transporting ATPase activity
GO:0046872	metal ion binding

Biological Process

GO:0006810	transport
GO:0006812	cation transport
GO:0006816	calcium ion transport
GO:0007596	blood coagulation
GO:0008152	metabolic process
GO:0034220	ion transmembrane transport
GO:0055085	transmembrane transport
GO:0070588	calcium ion transmembrane transport

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane
GO:0016529	sarcoplasmic reticulum
GO:0031095	platelet dense tubular network membrane
GO:0031965	nuclear membrane
GO:0033017	sarcoplasmic reticulum membrane