Version 5.4
Mus musculus Gene: Arl2bp
Summary
InnateDB Gene IDBG-182520.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Arl2bp
Gene Name ADP-ribosylation factor-like 2 binding protein
Synonyms 1700010P10Rik; 1700027H16Rik; 6330544B05Rik; AI482273; AI849834; BART; Bart1
Species Mus musculus
Ensembl Gene ENSMUSG00000031776
Encoded Proteins
IDBP-182522
ADP-ribosylation factor-like 2 binding protein
IDBP-262202
ADP-ribosylation factor-like 2 binding protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000102931:
ADP-ribosylation factor (ARF)-like proteins (ARLs) comprise a functionally distinct group of the ARF family of RAS-related GTPases. The protein encoded by this gene binds to ARL2.GTP with high affinity but does not interact with ARL2.GDP, activated ARF, or RHO proteins. The lack of detectable membrane association of this protein or ARL2 upon activation of ARL2 is suggestive of actions distinct from those of the ARFs. This protein is considered to be the first ARL2-specific effector identified, due to its interaction with ARL2.GTP but lack of ARL2 GTPase-activating protein activity. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:94666755-94674417
Strand Forward strand
Band C5
Transcripts
ENSMUST00000034228 ENSMUSP00000034228
ENSMUST00000109527 ENSMUSP00000105153
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
GO:0005083 small GTPase regulator activity
GO:0005515 protein binding
Biological Process
GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0050790 regulation of catalytic activity
GO:0051457 maintenance of protein location in nucleus
GO:2001141 regulation of RNA biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005758 mitochondrial intermembrane space
GO:0005813 centrosome
GO:0005929 cilium
GO:0030496 midbody
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000102931
View Gene Order
ENSBTAG00000004844
Not yet available
Cross-References
SwissProt Q9D385
TrEMBL
UniProt Splice Variant
Entrez Gene 107566
UniGene Mm.393247 Mm.488471
RefSeq NM_024191 NM_024269
OMIM
CCDS CCDS22545 CCDS40440
HPRD
IMGT
MGI ID MGI:1349429
MGI Symbol Arl2bp
EMBL AK006418 AK006646 AK018229 AK155242 AK161325 BC002131 BC024708 CT010168
GenPept AAH02131 AAH24708 BAB24578 BAB24686 BAB31126 BAE33143 BAE36323 CAJ18376
RNA Seq Atlas 107566

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca