Version 5.4
Mus musculus Gene: Lepre1
Summary
InnateDB Gene IDBG-182649.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lepre1
Gene Name leprecan 1
Synonyms 2410024C15Rik; Gros1; P3H1
Species Mus musculus
Ensembl Gene ENSMUSG00000028641
Encoded Proteins
IDBP-182651
leprecan 1
IDBP-182653
leprecan 1
IDBP-182655
leprecan 1
IDBP-400295
leprecan 1
IDBP-532166
leprecan 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000117385:
This gene encodes an enzyme that is a member of the collagen prolyl hydroxylase family. These enzymes are localized to the endoplasmic reticulum and their activity is required for proper collagen synthesis and assembly. Mutations in this gene are associated with osteogenesis imperfecta type VIII. Three alternatively spliced transcript variants encoding different isoforms have been described. Other variants may exist, but their biological validity has not been determined. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:119232915-119248975
Strand Forward strand
Band D2.1
Transcripts
ENSMUST00000030393 ENSMUSP00000030393
ENSMUST00000102662 ENSMUSP00000099723
ENSMUST00000081606 ENSMUSP00000080312
ENSMUST00000121111 ENSMUSP00000112504
ENSMUST00000153940
ENSMUST00000136278 ENSMUSP00000119695
ENSMUST00000126056
ENSMUST00000131875
ENSMUST00000123963
ENSMUST00000142361
ENSMUST00000134548
ENSMUST00000127087
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005506 iron ion binding
GO:0016491 oxidoreductase activity
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0019797 procollagen-proline 3-dioxygenase activity
GO:0031418 L-ascorbic acid binding
Biological Process
GO:0006457 protein folding
GO:0016049 cell growth
GO:0018126 protein hydroxylation
GO:0019511 peptidyl-proline hydroxylation
GO:0030199 collagen fibril organization
GO:0030278 regulation of ossification
GO:0032963 collagen metabolic process
GO:0050708 regulation of protein secretion
GO:0050821 protein stabilization
GO:0055114 oxidation-reduction process
GO:0060348 bone development
GO:1901874 negative regulation of post-translational protein modification
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000117385
View Gene Order
ENSBTAG00000017382
Not yet available
Pathways
NETPATH
REACTOME
REACT_199045
Collagen formation pathway
REACT_198984
Collagen biosynthesis and modifying enzymes pathway
REACT_206066
Extracellular matrix organization pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_121139
Collagen biosynthesis and modifying enzymes pathway
REACT_118779
Extracellular matrix organization pathway
REACT_120729
Collagen formation pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q3V1T4
TrEMBL F2Z499
UniProt Splice Variant
Entrez Gene 56401
UniGene Mm.27961
RefSeq NM_019783 NM_001042411 NM_001286148 NM_019782
OMIM
CCDS CCDS38859 CCDS18576 CCDS38860 CCDS71460
HPRD
IMGT
MGI ID MGI:1888921
MGI Symbol Lepre1
EMBL AF165163 AF165164 AK010578 AK030436 AK132262 AK159505 AL606975 BC024047
GenPept AAF04806 AAF04807 AAH24047 BAB27041 BAC26962 BAE21065 BAE35138 CAM21645 CAO78098
RNA Seq Atlas 56401

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca