InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ybx1

Summary

InnateDB Gene

IDBG-182925.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ybx1

Gene Name

Y box protein 1

Synonyms

1700102N10Rik; C79409; dbpB; EF1A; MSY1; mYB-1a; Nsep1; YB-1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028639

Encoded Proteins

IDBP-182927

Y box protein 1

IDBP-540695

Y box protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 25398005

Ybx1 controls intracellular Il6 mRNA levels in a cell type-specific manner, leading to functions that are dependent on the extracellular and intracellular distribution of Ybx1.

PMID 26026270

Bacterial cell wall glucosaminyl-muramyl dipeptides (GMDPs) bind to the transcription factor Ybx1 to upregulate Nfkb2 and Cxcr4 gene expression.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000065978:

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:119277981-119294604

Strand

Reverse strand

Band

D2.1

Transcripts

ENSMUST00000079644	ENSMUSP00000078589
ENSMUST00000127737	ENSMUSP00000117225
ENSMUST00000145976
ENSMUST00000144992
ENSMUST00000139897
ENSMUST00000142884
ENSMUST00000152733

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 85 experimentally validated interaction(s) in this database.
They are also associated with 112 interaction(s) predicted by orthology.

Experimentally validated
Total	85 [view]
Protein-Protein	84 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	112 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003697	single-stranded DNA binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001701	in utero embryonic development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006397	mRNA processing
GO:0008380	RNA splicing
GO:0045087	innate immune response (InnateDB)
GO:0051154	negative regulation of striated muscle cell differentiation
GO:0051781	positive regulation of cell division
GO:0070934	CRD-mediated mRNA stabilization

Cellular Component

GO:0005634	nucleus
GO:0005689	U12-type spliceosomal complex
GO:0005737	cytoplasm
GO:0010494	cytoplasmic stress granule
GO:0030529	ribonucleoprotein complex
GO:0031965	nuclear membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome
GO:0070937	CRD-mediated mRNA stability complex
GO:0071204	histone pre-mRNA 3'end processing complex