Version 5.4
Mus musculus Gene: Cops4
Summary
InnateDB Gene IDBG-183285.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cops4
Gene Name COP9 (constitutive photomorphogenic) homolog, subunit 4 (Arabidopsis thaliana)
Synonyms AW208976; D5Ertd774e
Species Mus musculus
Ensembl Gene ENSMUSG00000035297
Encoded Proteins
IDBP-183287
COP9 (constitutive photomorphogenic) homolog, subunit 4 (Arabidopsis thaliana)
IDBP-538839
COP9 (constitutive photomorphogenic) homolog, subunit 4 (Arabidopsis thaliana)
IDBP-542766
COP9 (constitutive photomorphogenic) homolog, subunit 4 (Arabidopsis thaliana)
IDBP-540329
COP9 (constitutive photomorphogenic) homolog, subunit 4 (Arabidopsis thaliana)
IDBP-540704
COP9 (constitutive photomorphogenic) homolog, subunit 4 (Arabidopsis thaliana)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000138663:
This gene encodes one of eight subunits composing COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:100518309-100547803
Strand Forward strand
Band E4
Transcripts
ENSMUST00000045993 ENSMUSP00000048416
ENSMUST00000147729
ENSMUST00000151414 ENSMUSP00000114585
ENSMUST00000123069 ENSMUSP00000115767
ENSMUST00000146476 ENSMUSP00000121979
ENSMUST00000123492 ENSMUSP00000119737
ENSMUST00000123559
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 65 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 65 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000338 protein deneddylation
GO:0010388 cullin deneddylation
Cellular Component
GO:0005634 nucleus
GO:0008021 synaptic vesicle
GO:0008180 COP9 signalosome
GO:0030054 cell junction
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000138663
View Gene Order
ENSBTAG00000006950
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.957
RefSeq NM_012001 XM_006534954
OMIM
CCDS CCDS19463
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca