InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CRKL

Summary

InnateDB Gene

IDBG-1833.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CRKL

Gene Name

v-crk sarcoma virus CT10 oncogene homolog (avian)-like

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000099942

Encoded Proteins

IDBP-1835

v-crk sarcoma virus CT10 oncogene homolog (avian)-like

IDBP-364123

v-crk sarcoma virus CT10 oncogene homolog (avian)-like

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 9872990

A type-I-IFN receptor that functions as a nuclear adapter protein and associates with STAT5 to regulate gene transcription through DNA binding

PMID 24145029

Enterohemorrhagic E. coli NleH1 effector targets CRKL to inhibit ribosomal protein S3 nuclear translocation and the NFκB pathway.

Entrez Gene

Summary

This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.[provided by RefSeq, Jan 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 22:20917426-20953749

Strand

Forward strand

Band

q11.21

Transcripts

ENST00000354336	ENSP00000346300
ENST00000411769	ENSP00000396646

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 110 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	110 [view]
Protein-Protein	109 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005070	SH3/SH2 adaptor activity
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000186	activation of MAPKK activity
GO:0001568	blood vessel development
GO:0007254	JNK cascade
GO:0007265	Ras protein signal transduction
GO:0007389	pattern specification process
GO:0007507	heart development
GO:0009887	organ morphogenesis
GO:0009952	anterior/posterior pattern specification
GO:0009967	positive regulation of signal transduction
GO:0035556	intracellular signal transduction
GO:0045087	innate immune response (InnateDB)
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048538	thymus development
GO:0060017	parathyroid gland development