Version 5.4
Mus musculus Gene: Farp2
Summary
InnateDB Gene IDBG-183444.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Farp2
Gene Name FERM, RhoGEF and pleckstrin domain protein 2
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000034066
Encoded Proteins
IDBP-400748
FERM, RhoGEF and pleckstrin domain protein 2
IDBP-400743
FERM, RhoGEF and pleckstrin domain protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000006607:
Gene Information
Type Protein coding
Genomic Location Chromosome 1:93512079-93621976
Strand Forward strand
Band D
Transcripts
ENSMUST00000120301 ENSMUSP00000112725
ENSMUST00000122402 ENSMUSP00000113790
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0008092 cytoskeletal protein binding
GO:0030676 Rac guanyl-nucleotide exchange factor activity
Biological Process
GO:0007155 cell adhesion
GO:0016322 neuron remodeling
GO:0016601 Rac protein signal transduction
GO:0030316 osteoclast differentiation
GO:0031532 actin cytoskeleton reorganization
GO:0032314 regulation of Rac GTPase activity
GO:0032319 regulation of Rho GTPase activity
GO:0032321 positive regulation of Rho GTPase activity
GO:0033623 regulation of integrin activation
GO:0035023 regulation of Rho protein signal transduction
GO:0071526 semaphorin-plexin signaling pathway
GO:0071800 podosome assembly
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0019898 extrinsic component of membrane
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000006607
View Gene Order
Pathways
NETPATH
REACTOME
REACT_246154
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion pathway
REACT_261444
Axon guidance pathway
REACT_188576
Developmental Biology pathway
REACT_263034
Semaphorin interactions pathway
KEGG
mmu04520
Adherens junction pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_19279
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion pathway
REACT_111045
Developmental Biology pathway
REACT_19271
Semaphorin interactions pathway
REACT_18266
Axon guidance pathway
KEGG
hsa04520
Adherens junction pathway
INOH
PID NCI
nectin_pathway
Nectin adhesion pathway
cdc42_reg_pathway
Regulation of CDC42 activity
Cross-References
SwissProt
TrEMBL D3Z4C0
UniProt Splice Variant
Entrez Gene 227377
UniGene Mm.243091
RefSeq NM_145519
OMIM
CCDS CCDS15191
HPRD
IMGT
MGI ID MGI:2385126
MGI Symbol Farp2
EMBL AC108412 AC131316
GenPept
RNA Seq Atlas 227377

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca