Version 5.4
Mus musculus Gene: Stk25
Summary
InnateDB Gene IDBG-183622.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Stk25
Gene Name serine/threonine kinase 25 (yeast)
Synonyms 1500019J11Rik; AU018434; C86992; Ste20-like; Ysk1
Species Mus musculus
Ensembl Gene ENSMUSG00000026277
Encoded Proteins
IDBP-183624
serine/threonine kinase 25 (yeast)
IDBP-538673
serine/threonine kinase 25 (yeast)
IDBP-789830
serine/threonine kinase 25 (yeast)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115694:
This gene encodes a member of the germinal centre kinase III (GCK III) subfamily of the sterile 20 superfamily of kinases. The encoded enzyme plays a role in serine-threonine liver kinase B1 (LKB1) signaling pathway to regulate neuronal polarization and morphology of the Golgi apparatus. The protein is translocated from the Golgi apparatus to the nucleus in response to chemical anoxia and plays a role in regulation of cell death. A pseudogene associated with this gene is located on chromosome 18. Multiple alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:93619751-93658659
Strand Reverse strand
Band D
Transcripts
ENSMUST00000027498 ENSMUSP00000027498
ENSMUST00000151068
ENSMUST00000154008
ENSMUST00000125778
ENSMUST00000133769 ENSMUSP00000117765
ENSMUST00000186287 ENSMUSP00000140396
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 33 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004702 receptor signaling protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
Biological Process
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0007163 establishment or maintenance of cell polarity
GO:0023014 signal transduction by phosphorylation
GO:0035556 intracellular signal transduction
GO:0050772 positive regulation of axonogenesis
GO:0051645 Golgi localization
Cellular Component
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000115694
View Gene Order
ENSBTAG00000009676
Not yet available
Cross-References
SwissProt Q9Z2W1
TrEMBL D3Z359
UniProt Splice Variant
Entrez Gene 59041
UniGene Mm.28761
RefSeq NM_021537 XM_006529768
OMIM
CCDS CCDS15192
HPRD
IMGT
MGI ID MGI:1891699
MGI Symbol Stk25
EMBL AC131316 AF004934 AK148041 BC071218 CH466520
GenPept AAD01208 AAH71218 BAE28307 EDL39941 EDL39942
RNA Seq Atlas 59041

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca