InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Gpd1

Summary

InnateDB Gene

IDBG-183789.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gpd1

Gene Name

glycerol-3-phosphate dehydrogenase 1 (soluble)

Synonyms

AI747587; Gdc-1; Gdc1; mKIAA4010

Species

Mus musculus

Ensembl Gene

ENSMUSG00000023019

Encoded Proteins

IDBP-183791

glycerol-3-phosphate dehydrogenase 1 (soluble)

IDBP-534779

glycerol-3-phosphate dehydrogenase 1 (soluble)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000167588:
This gene encodes a member of the NAD-dependent glycerol-3-phosphate dehydrogenase family. The encoded protein plays a critical role in carbohydrate and lipid metabolism by catalyzing the reversible conversion of dihydroxyacetone phosphate (DHAP) and reduced nicotine adenine dinucleotide (NADH) to glycerol-3-phosphate (G3P) and NAD+. The encoded cytosolic protein and mitochondrial glycerol-3-phosphate dehydrogenase also form a glycerol phosphate shuttle that facilitates the transfer of reducing equivalents from the cytosol to mitochondria. Mutations in this gene are a cause of transient infantile hypertriglyceridemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:99717515-99725005

Strand

Forward strand

Band

Transcripts

ENSMUST00000023760	ENSMUSP00000023760
ENSMUST00000162194	ENSMUSP00000125164
ENSMUST00000161768

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004367	glycerol-3-phosphate dehydrogenase [NAD+] activity
GO:0004368	glycerol-3-phosphate dehydrogenase activity
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0042803	protein homodimerization activity
GO:0051287	NAD binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006072	glycerol-3-phosphate metabolic process
GO:0006094	gluconeogenesis
GO:0006116	NADH oxidation
GO:0006127	glycerophosphate shuttle
GO:0006734	NADH metabolic process
GO:0045821	positive regulation of glycolytic process
GO:0046168	glycerol-3-phosphate catabolic process
GO:0046486	glycerolipid metabolic process
GO:0055114	oxidation-reduction process
GO:0071320	cellular response to cAMP
GO:0071356	cellular response to tumor necrosis factor

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0009331	glycerol-3-phosphate dehydrogenase complex
GO:0070062	extracellular vesicular exosome