Version 5.4
Mus musculus Gene: D2hgdh
Summary
InnateDB Gene IDBG-183947.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol D2hgdh
Gene Name D-2-hydroxyglutarate dehydrogenase
Synonyms AA408776; AA408778; AI325464
Species Mus musculus
Ensembl Gene ENSMUSG00000073609
Encoded Proteins
IDBP-183949
D-2-hydroxyglutarate dehydrogenase
IDBP-255048
D-2-hydroxyglutarate dehydrogenase
IDBP-789878
D-2-hydroxyglutarate dehydrogenase
IDBP-789881
D-2-hydroxyglutarate dehydrogenase
IDBP-789882
D-2-hydroxyglutarate dehydrogenase
IDBP-789884
D-2-hydroxyglutarate dehydrogenase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000180902:
This gene encodes D-2hydroxyglutarate dehydrogenase, a mitochondrial enzyme belonging to the FAD-binding oxidoreductase/transferase type 4 family. This enzyme, which is most active in liver and kidney but also active in heart and brain, converts D-2-hydroxyglutarate to 2-ketoglutarate. Mutations in this gene are present in D-2-hydroxyglutaric aciduria, a rare recessive neurometabolic disorder causing developmental delay, epilepsy, hypotonia, and dysmorphic features. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:93824909-93852348
Strand Forward strand
Band D
Transcripts
ENSMUST00000097633 ENSMUSP00000095235
ENSMUST00000112881 ENSMUSP00000108502
ENSMUST00000149397
ENSMUST00000141701
ENSMUST00000187321 ENSMUSP00000140181
ENSMUST00000189154 ENSMUSP00000140506
ENSMUST00000186783 ENSMUSP00000139770
ENSMUST00000188532 ENSMUSP00000139812
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0008762 UDP-N-acetylmuramate dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0016614 oxidoreductase activity, acting on CH-OH group of donors
GO:0050660 flavin adenine dinucleotide binding
GO:0051990 (R)-2-hydroxyglutarate dehydrogenase activity
Biological Process
GO:0010042 response to manganese ion
GO:0010043 response to zinc ion
GO:0032025 response to cobalt ion
GO:0044267 cellular protein metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000180902
View Gene Order
ENSBTAG00000002847
Not yet available
Pathways
NETPATH
REACTOME
REACT_189162
The citric acid (TCA) cycle and respiratory electron transport pathway
REACT_188937
Metabolism pathway
REACT_241308
Pyruvate metabolism and Citric Acid (TCA) cycle pathway
REACT_198633
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_25367
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate pathway
REACT_1046
Pyruvate metabolism and Citric Acid (TCA) cycle pathway
REACT_111083
The citric acid (TCA) cycle and respiratory electron transport pathway
REACT_111217
Metabolism pathway
REACT_215469
The citric acid (TCA) cycle and respiratory electron transport pathway
REACT_211303
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate pathway
REACT_219139
Metabolism pathway
REACT_220485
Pyruvate metabolism and Citric Acid (TCA) cycle pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.383401
RefSeq NM_178882 XM_006529968 XM_006529969
OMIM
CCDS CCDS15196
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca