InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Adora2b

Summary

InnateDB Gene

IDBG-184026.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Adora2b

Gene Name

adenosine A2b receptor

Synonyms

A2b; A2BAR; A2BR; AA2BR; AI480866; AI605384

Species

Mus musculus

Ensembl Gene

ENSMUSG00000018500

Encoded Proteins

IDBP-184028

adenosine A2b receptor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000170425:
This gene encodes an adenosine receptor that is a member of the G protein-coupled receptor superfamily. This integral membrane protein stimulates adenylate cyclase activity in the presence of adenosine. This protein also interacts with netrin-1, which is involved in axon elongation. The gene is located near the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:62248984-62266453

Strand

Forward strand

Band

Transcripts

ENSMUST00000018644

ENSMUSP00000018644

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001609	G-protein coupled adenosine receptor activity
GO:0004930	G-protein coupled receptor activity

Biological Process

GO:0001973	adenosine receptor signaling pathway
GO:0002882	positive regulation of chronic inflammatory response to non-antigenic stimulus
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0010575	positive regulation vascular endothelial growth factor production
GO:0030819	positive regulation of cAMP biosynthetic process
GO:0030828	positive regulation of cGMP biosynthetic process
GO:0031284	positive regulation of guanylate cyclase activity
GO:0031668	cellular response to extracellular stimulus
GO:0032722	positive regulation of chemokine production
GO:0032755	positive regulation of interleukin-6 production
GO:0043306	positive regulation of mast cell degranulation
GO:0060087	relaxation of vascular smooth muscle