Version 5.4
Homo sapiens Gene: SIRT6
Summary
InnateDB Gene IDBG-18419.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SIRT6
Gene Name sirtuin 6
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000077463
Encoded Proteins
IDBP-18421
sirtuin 6
IDBP-18423
sirtuin 6
IDBP-762422
IDBP-765365
IDBP-765528
IDBP-765696
IDBP-765155
IDBP-765564
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:4174109-4182604
Strand Reverse strand
Band p13.3
Transcripts
ENST00000337491 ENSP00000337332
ENST00000305232 ENSP00000305310
ENST00000595670
ENST00000599365 ENSP00000473085
ENST00000601069
ENST00000594341
ENST00000600938 ENSP00000471123
ENST00000597896 ENSP00000470215
ENST00000596119
ENST00000601571 ENSP00000471837
ENST00000600540
ENST00000594279 ENSP00000472023
ENST00000599394
ENST00000596298
ENST00000601488 ENSP00000469001
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 30 [view]
Protein-Protein 30 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0003950 NAD+ ADP-ribosyltransferase activity
GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0017136 NAD-dependent histone deacetylase activity
GO:0046969 NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0070403 NAD+ binding
Biological Process
GO:0006471 protein ADP-ribosylation
GO:0010569 regulation of double-strand break repair via homologous recombination
GO:0016575 histone deacetylation
GO:0070932 histone H3 deacetylation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005724 nuclear telomeric heterochromatin
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000034748
View Gene Order
ENSBTAG00000019909
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.423756
RefSeq NM_001193285 NM_016539 XM_005259575 XM_005259577
HUGO
OMIM
CCDS CCDS12122 CCDS54199
HPRD 12093
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca