Version 5.4
Mus musculus Gene: Isl1
Summary
InnateDB Gene IDBG-184340.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Isl1
Gene Name ISL1 transcription factor, LIM/homeodomain
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000042258
Encoded Proteins
IDBP-184342
ISL1 transcription factor, LIM/homeodomain
IDBP-713935
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000016082:
This gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:116298281-116309689
Strand Reverse strand
Band D2.2
Transcripts
ENSMUST00000036060 ENSMUSP00000044879
ENSMUST00000177469
ENSMUST00000176044 ENSMUSP00000135567
ENSMUST00000176812
ENSMUST00000176444
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001102 RNA polymerase II activating transcription factor binding
GO:0001105 RNA polymerase II transcription coactivator activity
GO:0001158 enhancer sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016922 ligand-dependent nuclear receptor binding
GO:0030331 estrogen receptor binding
GO:0043425 bHLH transcription factor binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001755 neural crest cell migration
GO:0003007 heart morphogenesis
GO:0003139 secondary heart field specification
GO:0003148 outflow tract septum morphogenesis
GO:0003151 outflow tract morphogenesis
GO:0003203 endocardial cushion morphogenesis
GO:0003215 cardiac right ventricle morphogenesis
GO:0003266 regulation of secondary heart field cardioblast proliferation
GO:0006355 regulation of transcription, DNA-templated
GO:0007507 heart development
GO:0008284 positive regulation of cell proliferation
GO:0010468 regulation of gene expression
GO:0010575 positive regulation vascular endothelial growth factor production
GO:0021520 spinal cord motor neuron cell fate specification
GO:0021522 spinal cord motor neuron differentiation
GO:0021524 visceral motor neuron differentiation
GO:0021559 trigeminal nerve development
GO:0021983 pituitary gland development
GO:0030182 neuron differentiation
GO:0031016 pancreas development
GO:0031103 axon regeneration
GO:0031290 retinal ganglion cell axon guidance
GO:0032024 positive regulation of insulin secretion
GO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production
GO:0032729 positive regulation of interferon-gamma production
GO:0032730 positive regulation of interleukin-1 alpha production
GO:0032731 positive regulation of interleukin-1 beta production
GO:0032735 positive regulation of interleukin-12 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway
GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0043388 positive regulation of DNA binding
GO:0043524 negative regulation of neuron apoptotic process
GO:0045665 negative regulation of neuron differentiation
GO:0045766 positive regulation of angiogenesis
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048663 neuron fate commitment
GO:0048665 neuron fate specification
GO:0048762 mesenchymal cell differentiation
GO:0048880 sensory system development
GO:0048935 peripheral nervous system neuron development
GO:0048936 peripheral nervous system neuron axonogenesis
GO:0050728 negative regulation of inflammatory response
GO:0055010 ventricular cardiac muscle tissue morphogenesis
GO:0060037 pharyngeal system development
GO:0060379 cardiac muscle cell myoblast differentiation
GO:0060384 innervation
GO:0060413 atrial septum morphogenesis
GO:0060913 cardiac cell fate determination
GO:0071385 cellular response to glucocorticoid stimulus
GO:0071657 positive regulation of granulocyte colony-stimulating factor production
GO:0090074 negative regulation of protein homodimerization activity
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:1901258 positive regulation of macrophage colony-stimulating factor production
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000016082
View Gene Order
ENSBTAG00000001241
Not yet available
Pathways
NETPATH
REACTOME
REACT_230557
Incretin synthesis, secretion, and inactivation pathway
REACT_247926
Metabolism of proteins pathway
REACT_206913
Peptide hormone metabolism pathway
REACT_253751
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_23824
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) pathway
REACT_23974
Incretin synthesis, secretion, and inactivation pathway
REACT_17015
Metabolism of proteins pathway
REACT_160078
Peptide hormone metabolism pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt P61372
TrEMBL A2RSV5
UniProt Splice Variant
Entrez Gene 16392
UniGene Mm.405911 Mm.42242
RefSeq NM_021459
OMIM
CCDS CCDS26790
HPRD
IMGT
MGI ID MGI:101791
MGI Symbol Isl1
EMBL AB104633 AJ132765 BC132263 BC132609 CH466568
GenPept AAI32264 AAI32610 BAC57891 CAB38446 EDL18368
RNA Seq Atlas 16392

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca