InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cap1

Summary

InnateDB Gene

IDBG-184645.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cap1

Gene Name

CAP, adenylate cyclase-associated protein 1 (yeast)

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028656

Encoded Proteins

IDBP-184647

CAP, adenylate cyclase-associated protein 1 (yeast)

IDBP-269149

CAP, adenylate cyclase-associated protein 1 (yeast)

IDBP-269151

CAP, adenylate cyclase-associated protein 1 (yeast)

IDBP-541524

CAP, adenylate cyclase-associated protein 1 (yeast)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The product of this gene plays a role in regulating actin dynamics by binding actin monomers and promoting the turnover of actin filaments. Reduced expression of this gene causes a reduction in actin filament turnover rates, causing multiple defects, including an increase in cell size, stress-fiber alterations, and defects in endocytosis and cell motility. A pseudogene of this gene is found on chromosome 14. Alternative splicing results in multiple transcript variants, but does not affect the protein. [provided by RefSeq, Jul 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:122859047-122886056

Strand

Reverse strand

Band

D2.2

Transcripts

ENSMUST00000069533	ENSMUSP00000068260
ENSMUST00000106257	ENSMUSP00000101864
ENSMUST00000106255	ENSMUSP00000101862
ENSMUST00000150919
ENSMUST00000128485	ENSMUSP00000114847
ENSMUST00000140783
ENSMUST00000151041

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding

Biological Process

GO:0000902	cell morphogenesis
GO:0001667	ameboidal cell migration
GO:0006898	receptor-mediated endocytosis
GO:0007010	cytoskeleton organization
GO:0030036	actin cytoskeleton organization

Cellular Component

GO:0005576	extracellular region
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0030864	cortical actin cytoskeleton
GO:0070062	extracellular vesicular exosome