Mus musculus Gene: Tfpi | |||||||
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Summary | |||||||
InnateDB Gene | IDBG-184676.6 | ||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||
Gene Symbol | Tfpi | ||||||
Gene Name | tissue factor pathway inhibitor | ||||||
Synonyms | A630013F22Rik; AW552122; EPI; LACI | ||||||
Species | Mus musculus | ||||||
Ensembl Gene | ENSMUSG00000027082 | ||||||
Encoded Proteins |
tissue factor pathway inhibitor
tissue factor pathway inhibitor
tissue factor pathway inhibitor
tissue factor pathway inhibitor
tissue factor pathway inhibitor
tissue factor pathway inhibitor
tissue factor pathway inhibitor
tissue factor pathway inhibitor
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Protein Structure | |||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||
Entrez Gene | |||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000003436:
This gene encodes a protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. The encoded protein is glycosylated and predominantly found in the vascular endothelium and plasma in both free forms and complexed with plasma lipoproteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been confirmed. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||
Type | Protein coding | ||||||
Genomic Location | Chromosome 2:84432855-84476775 | ||||||
Strand | Reverse strand | ||||||
Band | D | ||||||
Transcripts | |||||||
Interactions | |||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
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Gene Ontology | |||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||
Species
Homo sapiens
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Gene ID
Gene Order
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Pathways | |||||||
NETPATH | |||||||
REACTOME |
Hemostasis pathway
Extrinsic Pathway pathway
Formation of Fibrin Clot (Clotting Cascade) pathway
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KEGG |
Complement and coagulation cascades pathway
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INOH | |||||||
PID NCI | |||||||
Pathway Predictions based on Human Orthology Data | |||||||
NETPATH | |||||||
REACTOME |
Extrinsic Pathway pathway
Formation of Fibrin Clot (Clotting Cascade) pathway
Hemostasis pathway
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KEGG |
Complement and coagulation cascades pathway
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INOH | |||||||
PID NCI |
Syndecan-4-mediated signaling events
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Cross-References | |||||||
SwissProt | |||||||
TrEMBL | |||||||
UniProt Splice Variant | |||||||
Entrez Gene | |||||||
UniGene | Mm.124316 Mm.395995 Mm.487161 | ||||||
RefSeq | NM_001177319 NM_001177320 NM_011576 XM_006499145 XM_006499147 XM_006499148 | ||||||
OMIM | |||||||
CCDS | CCDS16185 CCDS50620 | ||||||
HPRD | |||||||
IMGT | |||||||
MGI ID | |||||||
MGI Symbol | |||||||
EMBL | |||||||
GenPept | |||||||
RNA Seq Atlas | |||||||