Version 5.4
Mus musculus Gene: Ctnnd1
Summary
InnateDB Gene IDBG-184766.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ctnnd1
Gene Name catenin (cadherin associated protein), delta 1
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000034101
Encoded Proteins
IDBP-184768
catenin (cadherin associated protein), delta 1
IDBP-184770
catenin (cadherin associated protein), delta 1
IDBP-184772
catenin (cadherin associated protein), delta 1
IDBP-184774
catenin (cadherin associated protein), delta 1
IDBP-257550
catenin (cadherin associated protein), delta 1
IDBP-257552
catenin (cadherin associated protein), delta 1
IDBP-257554
catenin (cadherin associated protein), delta 1
IDBP-257556
catenin (cadherin associated protein), delta 1
IDBP-257558
catenin (cadherin associated protein), delta 1
IDBP-257560
catenin (cadherin associated protein), delta 1
IDBP-257562
catenin (cadherin associated protein), delta 1
IDBP-257564
catenin (cadherin associated protein), delta 1
IDBP-257566
catenin (cadherin associated protein), delta 1
IDBP-257568
catenin (cadherin associated protein), delta 1
IDBP-257570
catenin (cadherin associated protein), delta 1
IDBP-257572
catenin (cadherin associated protein), delta 1
IDBP-257574
catenin (cadherin associated protein), delta 1
IDBP-257576
catenin (cadherin associated protein), delta 1
IDBP-257578
catenin (cadherin associated protein), delta 1
IDBP-257580
catenin (cadherin associated protein), delta 1
IDBP-257582
catenin (cadherin associated protein), delta 1
IDBP-257584
catenin (cadherin associated protein), delta 1
IDBP-257586
catenin (cadherin associated protein), delta 1
IDBP-257590
catenin (cadherin associated protein), delta 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 25773174
Ctnnd1 expressed in alveolar type II epithelial cells plays a critical role in regulating the innate immunity of the entire lung.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198561:
This gene encodes a member of the Armadillo protein family, which function in adhesion between cells and signal transduction. Multiple translation initiation codons and alternative splicing result in many different isoforms being translated. Not all of the full-length natures of the described transcript variants have been determined. Read-through transcription also exists between this gene and the neighboring upstream thioredoxin-related transmembrane protein 2 (TMX2) gene. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:84600071-84650765
Strand Reverse strand
Band D
Transcripts
ENSMUST00000067232 ENSMUSP00000064518
ENSMUST00000036811 ENSMUSP00000042543
ENSMUST00000066177 ENSMUSP00000065252
ENSMUST00000099941 ENSMUSP00000097524
ENSMUST00000111698 ENSMUSP00000107327
ENSMUST00000111697 ENSMUSP00000107326
ENSMUST00000111696 ENSMUSP00000107325
ENSMUST00000111695 ENSMUSP00000107324
ENSMUST00000111694 ENSMUSP00000107323
ENSMUST00000111693 ENSMUSP00000107322
ENSMUST00000111692 ENSMUSP00000107321
ENSMUST00000111691 ENSMUSP00000107320
ENSMUST00000111690 ENSMUSP00000107319
ENSMUST00000111689 ENSMUSP00000107318
ENSMUST00000111688 ENSMUSP00000107317
ENSMUST00000111687 ENSMUSP00000107316
ENSMUST00000111686 ENSMUSP00000107315
ENSMUST00000111685 ENSMUSP00000107314
ENSMUST00000111684 ENSMUSP00000107313
ENSMUST00000111678 ENSMUSP00000107307
ENSMUST00000111677 ENSMUSP00000107306
ENSMUST00000111676 ENSMUSP00000107305
ENSMUST00000111675 ENSMUSP00000107304
ENSMUST00000111670 ENSMUSP00000107299
ENSMUST00000145312
ENSMUST00000141151
ENSMUST00000150940
ENSMUST00000131926
ENSMUST00000126092
ENSMUST00000149317
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.
They are also associated with 41 interaction(s) predicted by orthology.
Experimentally validated
Total 45 [view]
Protein-Protein 45 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 41 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005488 binding
GO:0005515 protein binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0019904 protein domain specific binding
GO:0045296 cadherin binding
Biological Process
GO:0001738 morphogenesis of a polarized epithelium
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007155 cell adhesion
GO:0007420 brain development
GO:0007435 salivary gland morphogenesis
GO:0016055 Wnt signaling pathway
GO:0016337 single organismal cell-cell adhesion
GO:0030216 keratinocyte differentiation
GO:0045087 innate immune response (InnateDB)
GO:0060690 epithelial cell differentiation involved in salivary gland development
GO:0090090 negative regulation of canonical Wnt signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005913 cell-cell adherens junction
GO:0005915 zonula adherens
GO:0005923 tight junction
GO:0016020 membrane
GO:0030027 lamellipodium
GO:0030426 growth cone
GO:0030496 midbody
GO:0043197 dendritic spine
GO:0045202 synapse
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000198561
View Gene Order
ENSBTAG00000002411
Not yet available
Pathways
NETPATH
REACTOME
REACT_227951
Signaling by VEGF pathway
REACT_248094
Cell-cell junction organization pathway
REACT_230395
Adherens junctions interactions pathway
REACT_261840
VEGFR2 mediated vascular permeability pathway
REACT_257088
VEGFA-VEGFR2 Pathway pathway
REACT_188257
Signal Transduction pathway
REACT_241978
Cell junction organization pathway
REACT_223082
Cell-Cell communication pathway
KEGG
mmu04520
Adherens junction pathway
mmu04670
Leukocyte transendothelial migration pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
NetPath_24
TSLP pathway
REACTOME
REACT_19195
Adherens junctions interactions pathway
REACT_111155
Cell-Cell communication pathway
REACT_20676
Cell junction organization pathway
REACT_12529
Signaling by VEGF pathway
REACT_228016
VEGFR2 mediated vascular permeability pathway
REACT_111102
Signal Transduction pathway
REACT_228166
VEGFA-VEGFR2 Pathway pathway
REACT_19331
Cell-cell junction organization pathway
KEGG
hsa04520
Adherens junction pathway
hsa04670
Leukocyte transendothelial migration pathway
INOH
PID NCI
ecadherin_nascentaj_pathway
E-cadherin signaling in the nascent adherens junction
fgf_pathway
FGF signaling pathway
ecadherin_stabilization_pathway
Stabilization and expansion of the E-cadherin adherens junction
ecadherin_keratinocyte_pathway
E-cadherin signaling in keratinocytes
arf6_traffickingpathway
Arf6 trafficking events
ncadherinpathway
N-cadherin signaling events
ajdiss_2pathway
Posttranslational regulation of adherens junction stability and dissassembly
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.35738 Mm.412738
RefSeq NM_001085448 NM_001085449 NM_001085450 NM_001085453 NM_007615 XM_006498625 XM_006498626 XM_006498629 XM_006498630 XM_006498631 XM_006498632 XM_006498633 XM_006498634 XM_006498635 XM_006498636 XM_006498637 XM_006498638 XM_006498639
OMIM
CCDS CCDS16186 CCDS50621 CCDS50622 CCDS50623
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca