InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Scn8a

Summary

InnateDB Gene

IDBG-185291.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Scn8a

Gene Name

sodium channel, voltage-gated, type VIII, alpha

Synonyms

AI853486; C630029C19Rik; dmu; med; mnd-2; mnd2; NaCh6; Nav1.6; nmf2; nmf335; nmf58; nur14; seal

Species

Mus musculus

Ensembl Gene

ENSMUSG00000023033

Encoded Proteins

IDBP-185281

sodium channel, voltage-gated, type VIII, alpha

IDBP-185293

sodium channel, voltage-gated, type VIII, alpha

IDBP-263547

sodium channel, voltage-gated, type VIII, alpha

IDBP-263549

sodium channel, voltage-gated, type VIII, alpha

IDBP-263551

sodium channel, voltage-gated, type VIII, alpha

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000196876:
This gene encodes a member of the sodium channel alpha subunit gene family. The encoded protein forms the ion pore region of the voltage-gated sodium channel. This protein is essential for the rapid membrane depolarization that occurs during the formation of the action potential in excitable neurons. Mutations in this gene are associated with mental retardation, pancerebellar atrophy and ataxia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:100870683-101045929

Strand

Forward strand

Band

Transcripts

ENSMUST00000096198	ENSMUSP00000093912
ENSMUST00000082209	ENSMUSP00000080842
ENSMUST00000108910	ENSMUSP00000104538
ENSMUST00000108909	ENSMUSP00000104537
ENSMUST00000108908	ENSMUSP00000104536

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005248	voltage-gated sodium channel activity
GO:0005515	protein binding

Biological Process

GO:0006811	ion transport
GO:0006814	sodium ion transport
GO:0007517	muscle organ development
GO:0007605	sensory perception of sound
GO:0007626	locomotory behavior
GO:0007628	adult walking behavior
GO:0008344	adult locomotory behavior
GO:0009636	response to toxic substance
GO:0019228	neuronal action potential
GO:0034765	regulation of ion transmembrane transport
GO:0035725	sodium ion transmembrane transport
GO:0050905	neuromuscular process
GO:0055085	transmembrane transport
GO:0086010	membrane depolarization during action potential

Cellular Component

GO:0001518	voltage-gated sodium channel complex
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0030425	dendrite
GO:0034706	sodium channel complex
GO:0043025	neuronal cell body

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000196876

View Gene Order

ENSBTAG00000021339

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_22266

Interaction between L1 and Ankyrins pathway

REACT_22205

L1CAM interactions pathway

REACT_111045

Developmental Biology pathway

REACT_18266

Axon guidance pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.385012 Mm.396661 Mm.409617

RefSeq

NM_001077499 NM_011323 XM_006520651 XM_006520652 XM_006520653 XM_006520654 XM_006520655 XM_006520656 XM_006520657 XM_006520658

OMIM

CCDS

CCDS57010 CCDS57011

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas