Version 5.4
Homo sapiens Gene: LNX1
Summary
InnateDB Gene IDBG-18546.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LNX1
Gene Name ligand of numb-protein X 1, E3 ubiquitin protein ligase
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000072201
Encoded Proteins
IDBP-18548
ligand of numb-protein X 1
IDBP-18554
ligand of numb-protein X 1
IDBP-480635
ligand of numb-protein X 1
IDBP-485269
ligand of numb-protein X 1
IDBP-476152
ligand of numb-protein X 1
IDBP-484106
ligand of numb-protein X 1
IDBP-474287
ligand of numb-protein X 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a membrane-bound protein that is involved in signal transduction and protein interactions. The encoded product is an E3 ubiquitin-protein ligase, which mediates ubiquitination and subsequent proteasomal degradation of proteins containing phosphotyrosine binding (PTB) domains. This protein may play an important role in tumorogenesis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A pseudogene, which is located on chromosome 17, has been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:53459301-53701405
Strand Reverse strand
Band q12
Transcripts
ENST00000306888 ENSP00000302879
ENST00000263925 ENSP00000263925
ENST00000511398
ENST00000513421 ENSP00000426445
ENST00000510143 ENSP00000421897
ENST00000512247 ENSP00000424364
ENST00000507168 ENSP00000425135
ENST00000504299 ENSP00000423344
ENST00000504605
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 173 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 173 [view]
Protein-Protein 173 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0030165 PDZ domain binding
GO:0046872 metal ion binding
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0051260 protein homooligomerization
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029228
View Gene Order
ENSBTAG00000020658
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
notch_pathway
Notch signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.518760 Hs.617338 Hs.629493
RefSeq NM_001126328 NM_032622 XM_005265785 XM_005265786
HUGO
OMIM
CCDS CCDS3492 CCDS47057
HPRD 17287
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca