Version 5.4
Mus musculus Gene: Hsp90ab1
Summary
InnateDB Gene IDBG-185482.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hsp90ab1
Gene Name heat shock protein 90 alpha (cytosolic), class B member 1
Synonyms 90kDa; AL022974; C81438; Hsp84; Hsp84-1; Hsp90; Hspcb
Species Mus musculus
Ensembl Gene ENSMUSG00000023944
Encoded Proteins
IDBP-185484
heat shock protein 90 alpha (cytosolic), class B member 1
IDBP-533657
heat shock protein 90 alpha (cytosolic), class B member 1
IDBP-623373
heat shock protein 90 alpha (cytosolic), class B member 1
IDBP-623374
heat shock protein 90 alpha (cytosolic), class B member 1
IDBP-623377
heat shock protein 90 alpha (cytosolic), class B member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000096384:
This gene encodes a member of the heat shock protein 90 family; these proteins are involved in signal transduction, protein folding and degradation and morphological evolution. This gene encodes the constitutive form of the cytosolic 90 kDa heat-shock protein and is thought to play a role in gastric apoptosis and inflammation. Alternative splicing results in multiple transcript variants. Pseudogenes have been identified on multiple chromosomes. [provided by RefSeq, Dec 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:45567775-45573271
Strand Reverse strand
Band B3
Transcripts
ENSMUST00000024739 ENSMUSP00000024739
ENSMUST00000145205
ENSMUST00000146770
ENSMUST00000151306
ENSMUST00000130406 ENSMUSP00000119678
ENSMUST00000165127 ENSMUSP00000126239
ENSMUST00000166469 ENSMUSP00000127338
ENSMUST00000163966 ENSMUSP00000131601
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 72 experimentally validated interaction(s) in this database.
They are also associated with 528 interaction(s) predicted by orthology.
Experimentally validated
Total 72 [view]
Protein-Protein 71 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 528 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002134 UTP binding
GO:0002135 CTP binding
GO:0003725 double-stranded RNA binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0005525 GTP binding
GO:0017098 sulfonylurea receptor binding
GO:0019901 protein kinase binding
GO:0023026 MHC class II protein complex binding
GO:0030235 nitric-oxide synthase regulator activity
GO:0030911 TPR domain binding
GO:0032564 dATP binding
GO:0044325 ion channel binding
GO:0044822 poly(A) RNA binding
GO:0051082 unfolded protein binding
Biological Process
GO:0001890 placenta development
GO:0006457 protein folding
GO:0006950 response to stress
GO:0009651 response to salt stress
GO:0032092 positive regulation of protein binding
GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0033160 positive regulation of protein import into nucleus, translocation
GO:0043524 negative regulation of neuron apoptotic process
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045793 positive regulation of cell size
GO:0060334 regulation of interferon-gamma-mediated signaling pathway
GO:0060338 regulation of type I interferon-mediated signaling pathway
GO:0071353 cellular response to interleukin-4
GO:0071407 cellular response to organic cyclic compound
GO:0071902 positive regulation of protein serine/threonine kinase activity
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0008180 COP9 signalosome
GO:0009986 cell surface
GO:0016020 membrane
GO:0016234 inclusion body
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0031526 brush border membrane
GO:0042470 melanosome
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000096384
View Gene Order
Pathways
NETPATH
REACTOME
REACT_239142
Innate Immune System pathway
REACT_198374
Regulation of actin dynamics for phagocytic cup formation pathway
REACT_188957
Cellular responses to stress pathway
REACT_254306
Sema3A PAK dependent Axon repulsion pathway
REACT_230745
Immune System pathway
REACT_213550
HSF1-dependent transactivation pathway
REACT_198644
The NLRP3 inflammasome pathway
REACT_224790
Cellular response to heat stress pathway
REACT_198656
Inflammasomes pathway
REACT_261444
Axon guidance pathway
REACT_223784
Attenuation phase pathway
REACT_209368
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_225256
HSF1 activation pathway
REACT_188576
Developmental Biology pathway
REACT_206758
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
REACT_263034
Semaphorin interactions pathway
KEGG
mmu04612
Antigen processing and presentation pathway
mmu05215
Prostate cancer pathway
mmu05200
Pathways in cancer pathway
mmu04914
Progesterone-mediated oocyte maturation pathway
mmu04621
NOD-like receptor signaling pathway pathway
mmu04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_9
TNFalpha pathway
NetPath_11
TCR pathway
REACTOME
REACT_160086
Regulation of actin dynamics for phagocytic cup formation pathway
REACT_75808
The NLRP3 inflammasome pathway
REACT_75900
Inflammasomes pathway
REACT_19236
Sema3A PAK dependent Axon repulsion pathway
REACT_120956
Cellular responses to stress pathway
REACT_111045
Developmental Biology pathway
REACT_19271
Semaphorin interactions pathway
REACT_6802
Innate Immune System pathway
REACT_200624
Attenuation phase pathway
REACT_18266
Axon guidance pathway
REACT_75913
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
REACT_6900
Immune System pathway
REACT_200775
HSF1-dependent transactivation pathway
REACT_200819
Cellular response to heat stress pathway
REACT_160123
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_200744
HSF1 activation pathway
KEGG
hsa04612
Antigen processing and presentation pathway
hsa05215
Prostate cancer pathway
hsa05200
Pathways in cancer pathway
hsa04914
Progesterone-mediated oocyte maturation pathway
hsa04621
NOD-like receptor signaling pathway pathway
hsa04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
vegfr1_2_pathway
Signaling events mediated by VEGFR1 and VEGFR2
Cross-References
SwissProt
TrEMBL E9Q0C3
UniProt Splice Variant
Entrez Gene 15516
UniGene Mm.2180 Mm.246589 Mm.381250 Mm.413436
RefSeq NM_008302
OMIM
CCDS CCDS28812
HPRD
IMGT
MGI ID MGI:96247
MGI Symbol Hsp90ab1
EMBL AC163677
GenPept
RNA Seq Atlas 15516

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca