InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Nanog

Summary

InnateDB Gene

IDBG-185735.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nanog

Gene Name

Nanog homeobox

Synonyms

2410002E02Rik; ecat4; ENK

Species

Mus musculus

Ensembl Gene

ENSMUSG00000012396

Encoded Proteins

IDBP-185737

Nanog homeobox

IDBP-255712

Nanog homeobox

IDBP-255714

Nanog homeobox

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000111704:

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:122707489-122714633

Strand

Forward strand

Band

Transcripts

ENSMUST00000012540	ENSMUSP00000012540
ENSMUST00000112581	ENSMUSP00000108200
ENSMUST00000112580	ENSMUSP00000108199

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 288 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	288 [view]
Protein-Protein	278 [view]
Protein-DNA	10 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001158	enhancer sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001710	mesodermal cell fate commitment
GO:0001714	endodermal cell fate specification
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0008283	cell proliferation
GO:0008284	positive regulation of cell proliferation
GO:0008406	gonad development
GO:0009790	embryo development
GO:0009880	embryonic pattern specification
GO:0010033	response to organic substance
GO:0010454	negative regulation of cell fate commitment
GO:0010468	regulation of gene expression
GO:0017145	stem cell division
GO:0019827	stem cell maintenance
GO:0030154	cell differentiation
GO:0030514	negative regulation of BMP signaling pathway
GO:0032526	response to retinoic acid
GO:0035019	somatic stem cell maintenance
GO:0042664	negative regulation of endodermal cell fate specification
GO:0045595	regulation of cell differentiation
GO:0045596	negative regulation of cell differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045931	positive regulation of mitotic cell cycle
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048863	stem cell differentiation