Version 5.4
Mus musculus Gene: Amelx
Summary
InnateDB Gene IDBG-185836.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Amelx
Gene Name amelogenin X chromosome
Synonyms ALGN; Amel; Amg; AMGL; AMGX; LRAP; M100888; Rgsc888
Species Mus musculus
Ensembl Gene ENSMUSG00000031354
Encoded Proteins
IDBP-185838
amelogenin X chromosome
IDBP-256670
amelogenin X chromosome
IDBP-256672
amelogenin X chromosome
IDBP-256674
amelogenin X chromosome
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000125363:
This gene encodes a member of the amelogenin family of extracellular matrix proteins. Amelogenins are involved in biomineralization during tooth enamel development. Mutations in this gene cause X-linked amelogenesis imperfecta. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:169176114-169187200
Strand Reverse strand
Band F5
Transcripts
ENSMUST00000066112 ENSMUSP00000065966
ENSMUST00000112120 ENSMUSP00000107748
ENSMUST00000112119 ENSMUSP00000107747
ENSMUST00000112118 ENSMUSP00000107746
ENSMUST00000154923
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008083 growth factor activity
GO:0030345 structural constituent of tooth enamel
GO:0042802 identical protein binding
GO:0046848 hydroxyapatite binding
Biological Process
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0007275 multicellular organismal development
GO:0007584 response to nutrient
GO:0008283 cell proliferation
GO:0034505 tooth mineralization
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042493 response to drug
GO:0051592 response to calcium ion
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0005604 basement membrane
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0009986 cell surface
GO:0030139 endocytic vesicle
GO:0031012 extracellular matrix
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000125363
View Gene Order
Cross-References
SwissProt P63277
TrEMBL B2BY37
UniProt Splice Variant
Entrez Gene 11704
UniGene Mm.391342
RefSeq NM_009666 NM_001081978 NM_001290371 XM_006528692
OMIM
CCDS CCDS41214 CCDS41213
HPRD
IMGT
MGI ID MGI:88005
MGI Symbol Amelx
EMBL AK029358 AL805974 D31768 D31769 D83067 EU168857 M10095
GenPept AAA37218 ABY48714 BAA06546 BAA06547 BAA23665 BAC26415 CAM21303 CAM21304
RNA Seq Atlas 11704

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca