Version 5.4
Mus musculus Gene: Vegfa
Summary
InnateDB Gene IDBG-185847.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Vegfa
Gene Name vascular endothelial growth factor A
Synonyms Vegf; Vpf
Species Mus musculus
Ensembl Gene ENSMUSG00000023951
Encoded Proteins
IDBP-185849
vascular endothelial growth factor A
IDBP-185851
vascular endothelial growth factor A
IDBP-253703
vascular endothelial growth factor A
IDBP-253705
vascular endothelial growth factor A
IDBP-532221
vascular endothelial growth factor A
IDBP-623736
vascular endothelial growth factor A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21278304
Vegfa-induced tissue response, e.g. angiogenesis, is inhibited during RSV and Influenza viral infections. These effects were mediated by RIG-I and IFNR-dependent pathways, and consequently inhibited the Th2 inflammation response.
InnateDB Annotation from Orthologs
Summary
PMID 21278304
[Homo sapiens] VEGFA-induced tissue response, e.g. angiogenesis, is inhibited during RSV and Influenza viral infections. These effects were mediated by RIG-I and IFNR-dependent pathways, and consequently inhibited the Th2 inflammation response.
Entrez Gene
Summary This gene product is a member of the PDGF/VEGF growth factor family. It is a mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis, endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Also, alternative translation initiation from non-AUG (CUG) and AUG start sites in some transcript variants, give rise to additional isoforms. [provided by RefSeq, Jul 2008]
This gene product is a member of the PDGF/VEGF growth factor family. It is a mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis, endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Also, alternative translation initiation from non-AUG (CUG) and AUG start sites in some transcript variants, give rise to additional isoforms. The expression of some isoforms derived from AUG start codon is affected by a small upstream open reading frame, which is located within an internal ribosome entry site. [provided by RefSeq, Nov 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:46016993-46032377
Strand Reverse strand
Band C
Transcripts
ENSMUST00000071648 ENSMUSP00000071575
ENSMUST00000024747 ENSMUSP00000024747
ENSMUST00000113520 ENSMUSP00000109148
ENSMUST00000113519 ENSMUSP00000109147
ENSMUST00000150327
ENSMUST00000142351 ENSMUSP00000115883
ENSMUST00000133605
ENSMUST00000143985
ENSMUST00000142321
ENSMUST00000146149
ENSMUST00000167860 ENSMUSP00000131901
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 6 [view]
Protein-DNA 7 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 34 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001968 fibronectin binding
GO:0005102 receptor binding
GO:0005125 cytokine activity
GO:0005161 platelet-derived growth factor receptor binding
GO:0005172 vascular endothelial growth factor receptor binding
GO:0005515 protein binding
GO:0008083 growth factor activity
GO:0008201 heparin binding
GO:0038191 neuropilin binding
GO:0042056 chemoattractant activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043183 vascular endothelial growth factor receptor 1 binding
GO:0043184 vascular endothelial growth factor receptor 2 binding
GO:0046982 protein heterodimerization activity
GO:0048018 receptor agonist activity
GO:0050840 extracellular matrix binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001525 angiogenesis
GO:0001541 ovarian follicle development
GO:0001568 blood vessel development
GO:0001569 patterning of blood vessels
GO:0001666 response to hypoxia
GO:0001701 in utero embryonic development
GO:0001822 kidney development
GO:0001934 positive regulation of protein phosphorylation
GO:0001938 positive regulation of endothelial cell proliferation
GO:0001944 vasculature development
GO:0001974 blood vessel remodeling
GO:0002040 sprouting angiogenesis
GO:0002042 cell migration involved in sprouting angiogenesis
GO:0002052 positive regulation of neuroblast proliferation
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0002092 positive regulation of receptor internalization
GO:0002575 basophil chemotaxis
GO:0003007 heart morphogenesis
GO:0003151 outflow tract morphogenesis
GO:0003169 coronary vein morphogenesis
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007498 mesoderm development
GO:0007595 lactation
GO:0008283 cell proliferation
GO:0008284 positive regulation of cell proliferation
GO:0008360 regulation of cell shape
GO:0009409 response to cold
GO:0010595 positive regulation of endothelial cell migration
GO:0010628 positive regulation of gene expression
GO:0016477 cell migration
GO:0030212 hyaluronan metabolic process
GO:0030224 monocyte differentiation
GO:0030225 macrophage differentiation
GO:0030324 lung development
GO:0030335 positive regulation of cell migration
GO:0030855 epithelial cell differentiation
GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0031077 post-embryonic camera-type eye development
GO:0031334 positive regulation of protein complex assembly
GO:0031954 positive regulation of protein autophosphorylation
GO:0032147 activation of protein kinase activity
GO:0032793 positive regulation of CREB transcription factor activity
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0035148 tube formation
GO:0035767 endothelial cell chemotaxis
GO:0035924 cellular response to vascular endothelial growth factor stimulus
GO:0036303 lymph vessel morphogenesis
GO:0038033 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
GO:0038084 vascular endothelial growth factor signaling pathway
GO:0038091 positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
GO:0038190 VEGF-activated neuropilin signaling pathway
GO:0040007 growth
GO:0042088 T-helper 1 type immune response
GO:0042462 eye photoreceptor cell development
GO:0043066 negative regulation of apoptotic process
GO:0043117 positive regulation of vascular permeability
GO:0043129 surfactant homeostasis
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043406 positive regulation of MAP kinase activity
GO:0043524 negative regulation of neuron apoptotic process
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0045087 innate immune response (InnateDB)
GO:0045766 positive regulation of angiogenesis
GO:0045779 negative regulation of bone resorption
GO:0045785 positive regulation of cell adhesion
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048255 mRNA stabilization
GO:0048286 lung alveolus development
GO:0048469 cell maturation
GO:0048514 blood vessel morphogenesis
GO:0048593 camera-type eye morphogenesis
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0048666 neuron development
GO:0048739 cardiac muscle fiber development
GO:0048754 branching morphogenesis of an epithelial tube
GO:0048842 positive regulation of axon extension involved in axon guidance
GO:0048844 artery morphogenesis
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050918 positive chemotaxis
GO:0050927 positive regulation of positive chemotaxis
GO:0051272 positive regulation of cellular component movement
GO:0051781 positive regulation of cell division
GO:0051894 positive regulation of focal adhesion assembly
GO:0051897 positive regulation of protein kinase B signaling
GO:0060319 primitive erythrocyte differentiation
GO:0060426 lung vasculature development
GO:0060749 mammary gland alveolus development
GO:0060754 positive regulation of mast cell chemotaxis
GO:0060948 cardiac vascular smooth muscle cell development
GO:0060982 coronary artery morphogenesis
GO:0061419 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071456 cellular response to hypoxia
GO:0071542 dopaminergic neuron differentiation
GO:0071679 commissural neuron axon guidance
GO:0090037 positive regulation of protein kinase C signaling
GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis
GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis
GO:0090259 regulation of retinal ganglion cell axon guidance
GO:1900086 positive regulation of peptidyl-tyrosine autophosphorylation
GO:1900745 positive regulation of p38MAPK cascade
GO:1901492 positive regulation of lymphangiogenesis
GO:1901727 positive regulation of histone deacetylase activity
GO:1902336 positive regulation of retinal ganglion cell axon guidance
GO:1902533 positive regulation of intracellular signal transduction
GO:1902966 positive regulation of protein localization to early endosome
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0005576 extracellular region
GO:0005604 basement membrane
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0030141 secretory granule
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000112715
View Gene Order
ENSBTAG00000005339
Not yet available
Pathways
NETPATH
REACTOME
REACT_230203
Platelet degranulation pathway
REACT_224553
Hemostasis pathway
REACT_224551
VEGF ligand-receptor interactions pathway
REACT_188957
Cellular responses to stress pathway
REACT_227951
Signaling by VEGF pathway
REACT_199106
Cellular response to hypoxia pathway
REACT_243939
EPHA-mediated growth cone collapse pathway
REACT_245086
VEGFR2 mediated cell proliferation pathway
REACT_224879
Platelet activation, signaling and aggregation pathway
REACT_199109
Regulation of Hypoxia-inducible Factor (HIF) by oxygen pathway
REACT_199107
Regulation of gene expression by Hypoxia-inducible Factor pathway
REACT_258158
EPH-Ephrin signaling pathway
REACT_257088
VEGFA-VEGFR2 Pathway pathway
REACT_261444
Axon guidance pathway
REACT_188576
Developmental Biology pathway
REACT_205099
VEGF binds to VEGFR leading to receptor dimerization pathway
REACT_206166
Response to elevated platelet cytosolic Ca2+ pathway
REACT_188257
Signal Transduction pathway
KEGG
mmu04060
Cytokine-cytokine receptor interaction pathway
mmu05219
Bladder cancer pathway
mmu05211
Renal cell carcinoma pathway
mmu04370
VEGF signaling pathway pathway
mmu04150
mTOR signaling pathway pathway
mmu04510
Focal adhesion pathway
mmu05212
Pancreatic cancer pathway
mmu05200
Pathways in cancer pathway
INOH
INOH website
VEGF signaling pathway pathway
INOH website
GPCR signaling pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_318
Platelet degranulation pathway
REACT_1280
Response to elevated platelet cytosolic Ca2+ pathway
REACT_12583
VEGF binds to VEGFR leading to receptor dimerization pathway
REACT_12380
VEGF ligand-receptor interactions pathway
REACT_121092
Regulation of gene expression by Hypoxia-inducible Factor pathway
REACT_120956
Cellular responses to stress pathway
REACT_12529
Signaling by VEGF pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_111102
Signal Transduction pathway
REACT_120815
Regulation of Hypoxia-inducible Factor (HIF) by oxygen pathway
REACT_121311
Cellular response to hypoxia pathway
REACT_604
Hemostasis pathway
KEGG
hsa04150
mTOR signaling pathway pathway
hsa04370
VEGF signaling pathway pathway
hsa05211
Renal cell carcinoma pathway
hsa05219
Bladder cancer pathway
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04510
Focal adhesion pathway
hsa05212
Pancreatic cancer pathway
hsa05200
Pathways in cancer pathway
INOH
INOH website
VEGF signaling pathway pathway
INOH website
GPCR signaling pathway
PID NCI
vegf_vegfr_pathway
VEGF and VEGFR signaling network
integrin1_pathway
Beta1 integrin cell surface interactions
s1p_s1p1_pathway
S1P1 pathway
avb3_integrin_pathway
Integrins in angiogenesis
glypican_1pathway
Glypican 1 network
integrin_a9b1_pathway
Alpha9 beta1 integrin signaling events
plexind1_pathway
Plexin-D1 Signaling
hif2pathway
HIF-2-alpha transcription factor network
tcptp_pathway
Signaling events mediated by TCPTP
s1p_s1p3_pathway
S1P3 pathway
vegfr1_2_pathway
Signaling events mediated by VEGFR1 and VEGFR2
hif1_tfpathway
HIF-1-alpha transcription factor network
shp2_pathway
SHP2 signaling
integrin3_pathway
Beta3 integrin cell surface interactions
vegfr1_pathway
VEGFR1 specific signals
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.473100
RefSeq NM_001025250 NM_001025257 NM_001287057 NM_001287058 NM_009505
OMIM
CCDS CCDS28816 CCDS28817 CCDS28818 CCDS70817
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca