InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Myod1

Summary

InnateDB Gene

IDBG-186053.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Myod1

Gene Name

myogenic differentiation 1

Synonyms

AI503393; bHLHc1; MYF3; MyoD; Myod-1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000009471

Encoded Proteins

IDBP-186055

myogenic differentiation 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000129152:
This gene encodes a nuclear protein that belongs to the basic helix-loop-helix family of transcription factors and the myogenic factors subfamily. It regulates muscle cell differentiation by inducing cell cycle arrest, a prerequisite for myogenic initiation. The protein is also involved in muscle regeneration. It activates its own transcription which may stabilize commitment to myogenesis. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:46376474-46379092

Strand

Forward strand

Band

Transcripts

ENSMUST00000072514

ENSMUSP00000072330

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 78 experimentally validated interaction(s) in this database.
They are also associated with 66 interaction(s) predicted by orthology.

Experimentally validated
Total	78 [view]
Protein-Protein	63 [view]
Protein-DNA	13 [view]
Protein-RNA	2 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	66 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001047	core promoter binding
GO:0001228	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0019899	enzyme binding
GO:0031490	chromatin DNA binding
GO:0031625	ubiquitin protein ligase binding
GO:0035257	nuclear hormone receptor binding
GO:0043565	sequence-specific DNA binding
GO:0046982	protein heterodimerization activity
GO:0046983	protein dimerization activity

Biological Process

GO:0000381	regulation of alternative mRNA splicing, via spliceosome
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0007517	muscle organ development
GO:0007518	myoblast cell fate determination
GO:0007519	skeletal muscle tissue development
GO:0009267	cellular response to starvation
GO:0014904	myotube cell development
GO:0014908	myotube differentiation involved in skeletal muscle regeneration
GO:0035914	skeletal muscle cell differentiation
GO:0043415	positive regulation of skeletal muscle tissue regeneration
GO:0043484	regulation of RNA splicing
GO:0043503	skeletal muscle fiber adaptation
GO:0043966	histone H3 acetylation
GO:0043967	histone H4 acetylation
GO:0045445	myoblast differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048741	skeletal muscle fiber development
GO:0051146	striated muscle cell differentiation
GO:0051149	positive regulation of muscle cell differentiation
GO:0055007	cardiac muscle cell differentiation
GO:0071385	cellular response to glucocorticoid stimulus
GO:0071392	cellular response to estradiol stimulus
GO:0071453	cellular response to oxygen levels
GO:1901741	positive regulation of myoblast fusion